Abstract
The physicochemical and pharmacological properties of some natural derivatives of 2H-1-benzopyran-2-one (coumarin) have been studied, including decursinol and obtusifol, which are the most promising compounds for practical applications. Using high-resolution 1H and 13C NMR spectra in comparison to the published data, the structure of obtusifol is finally established. Decursinol exhibited the most pronounced antiarrhythmic activity on the model of calcium-chloride-induced arrhythmia in rats: in a doze of 0.5 mg-kg, this compound prevented the loss of experimental animals and restored the sinusoidal rhythm in 100% of cases. The therapeutic antiarrhythmic index (AI = LD50/ED50) of decursinol (AI = 470) significantly exceeds the values for well-known drugs such as quinidine, novocainamide, and lidocaine (AI = 16.5, 17.0 and 22.2, respectively). The antiarrhythmic activity of campestrinol and obtusifol was close to that of decursinol. It was found that obtusifol, decursinol, diumancal, and their analogs (representing calcium ion antagonists of the new generation) significantly influence the potential-dependent conductivity of calcium channels not only of the L-type (encountered in muscles, heart and vessels), but also of the N-and T-types, most widely distributed in the central nervous system and ganglion.
Similar content being viewed by others
References
A. Z. Abyshev, E. M. Agaev, and E. V. Semenov, in: Calcium Ion Antagonists: A New Generation [in Russian], Azerbaijan Medical University, Baku (2003), pp. 101–167.
A. Z. Abyshev, E. M. Agaev, and Yu. B. Kerimov, in: Chemistry and Pharmacology of Natural Coumarins [in Russian], Caspian Supplies, Baku (2003), pp. 57–80.
A. Z. Abyshev, P. P. Denisenko, D. Z. Abyshev, et al., Khim. Prir. Soedin., No. 5, 640–646 (1977).
B. E. Nielsen, Dansk Tidsskr. Farm., 44, 111–286 (1970).
V. F. F. Monteiro, L. Mathias, I. J. C. Vieira, et al., J. Braz. Chem. Soc., 13(2), 1–11 (2002).
A. Z. Abyshev, Khim. Prir. Soedin., No. 5, 562–566 (1978).
A. Z. Abyshev, N. Ya. Isaev, and Yu. B. Kerimov, Khim. Prir. Soedin., No. 5, 800–803 (1980).
A. Z. Abyshev, P. P. Denisenko, Yu. B. Kerimov, et al., Khim. Prir. Soedin., No. 5, 654–655 (1978).
N. F. Gashimov and G. A. Kuznetsova, Khim. Prir. Soedin., No. 3, 303–308 (1974).
A. Z. Abyshev and N. F. Gashimov, Khim. Prir. Soedin., No. 3, 401–403 (1979).
A. Z. Abyshev, V. P. Zmeikov, and I. P. Sidorova, Khim. Prir. Soedin., No. 3, 301–307 (1982).
Jr. M. Boeykens, N. De. Kimpe, A. Z. Abyshev, et al., Phytochemistry, V. 36, 1559 (1994).
A. Z. Abyshev, E. M. Agaev, A. A. Abdulla-zade, et al., The 8th International Congress “Phytopharm”, Mikkeli (Finland), (2004), pp. 217–221.
L. Szekeres, I. L. Papp, Experimental Cardiac Arrhythmias and Antiarrhythmic Drugs, Budapest (1971), pp. 40–41.
A. Z. Abyshev, E. V. Semenov, K. N. Mel’nikov, and E. M. Agaev, in: Ankardin (Diumancal): Calcium Ion Antagonist of New Generation [in Russian], Pravda, St. Petersburg (2002), pp. 14–27.
Author information
Authors and Affiliations
Additional information
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 11, pp. 27–30, November, 2006.
Rights and permissions
About this article
Cite this article
Abyshev, A.Z., Gindin, V.A., Semenov, E.V. et al. Structure and biological properties of 2H-1-benzopyran-2-one (coumarin) derivatives. Pharm Chem J 40, 607–610 (2006). https://doi.org/10.1007/s11094-006-0203-7
Received:
Issue Date:
DOI: https://doi.org/10.1007/s11094-006-0203-7