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Synthesis and biological activity of nitrogen-containing derivatives of methyl dehydroabietate

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Abstract

The biological activity of a series of new amino derivatives of dehydroabietic acid has been studied. 12-N,N-Diethylaminoacetyl-8,11,13-abietatrien-18-oate hydrochloride produces a calming effect, shows pronounced anxiolytic activity, and exhibits antipyretic action comparable with that of the reference drug (analgin).

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Authors and Affiliations

  1. Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, Perm, Russia

    I. A. Tolmacheva, A. V. Tarantin, A. A. Boteva, L. V. Anikina, Yu. B. Vikharev, V. V. Grishko & A. G. Tolstikov

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  1. I. A. Tolmacheva
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  2. A. V. Tarantin
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  3. A. A. Boteva
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  4. L. V. Anikina
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  5. Yu. B. Vikharev
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  6. V. V. Grishko
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  7. A. G. Tolstikov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 9, pp. 27–31, September, 2006.

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Tolmacheva, I.A., Tarantin, A.V., Boteva, A.A. et al. Synthesis and biological activity of nitrogen-containing derivatives of methyl dehydroabietate. Pharm Chem J 40, 489–493 (2006). https://doi.org/10.1007/s11094-006-0161-0

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  • DOI: https://doi.org/10.1007/s11094-006-0161-0

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