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Synthesis and anticoagulant activity of 1-aryl derivatives of tetrahydroisoquinolines

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Abstract

A series of 1-aryl-3,3-dimethyl-3,4-dihydroisoquinolines were obtained by three-component (one-pot) condensation of veratrole, isobutylene oxide, and aromatic nitriles and then reduced to the corresponding 1,2,3,4-tetrahydroisoquinolines. Hydrochlorides of the synthesized compounds were tested for anticoagulant activity.

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Authors and Affiliations

  1. Perm State University, Perm, Russia

    V. A. Glushkov, K. A. Arapov & O. N. Minova

  2. Perm State Pharmaceutical Academy, Perm, Russia

    N. G. Ismailova & B. Ya. Syropyatov

  3. Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, Perm, Russia

    V. A. Glushkov & Yu. V. Shklyaev

Authors
  1. V. A. Glushkov
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  2. K. A. Arapov
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  3. O. N. Minova
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  4. N. G. Ismailova
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  5. B. Ya. Syropyatov
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  6. Yu. V. Shklyaev
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 7, pp. 18–20, July, 2006.

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Glushkov, V.A., Arapov, K.A., Minova, O.N. et al. Synthesis and anticoagulant activity of 1-aryl derivatives of tetrahydroisoquinolines. Pharm Chem J 40, 363–366 (2006). https://doi.org/10.1007/s11094-006-0128-1

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  • DOI: https://doi.org/10.1007/s11094-006-0128-1

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