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Dynamic mechanism of epileptic seizures generation and propagation after ischemic stroke

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Abstract

Epilepsy is the second largest neurological disease which seriously threatens human life and health. The one important reason of inducing epileptic seizures is ischemic stroke which causes insufficient oxygen supply from blood vessels to neurons. However, few studies focus on the underlying mechanism of the generation and propagation of epileptic seizures after ischemic stroke by utilizing modeling methods. To explore the mechanism, this paper establishes a coupled network model consisting of neurons and astrocytes, and introduces a blood vessel to simulate the condition of ischemic stroke. First, we study the effect of the degree of vascular blockage on the generation of epileptic seizures. The results demonstrate that the important reason of epileptic seizures after ischemic stroke is the disruption of ion concentration gradient. Then, we study three factors that influence the epileptic seizures propagation after ischemic stroke: massive glutamate release, excessive receptor activation and high extracellular potassium concentration. The results demonstrate that massive glutamate acting on postsynaptic neurons and the excessive activation of glutamate receptors on postsynaptic neurons promote the epileptic seizures propagation in neuronal population, and massive glutamate acting on astrocytes and excessive activation of metabotropic glutamate receptors on presynaptic neurons inhibit the epileptic seizures propagation, and the potassium uptake by astrocytes suppresses the epileptic seizures propagation. The results are consistent with the experimental phenomena. The simulation results also shed light on the fact that astrocytes have neuroprotective effect. Our results on the generation and propagation of epileptic seizures after ischemic stroke could offer theoretical guidelines for the treatment of epileptic seizures after ischemic stroke.

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Data availability

The datasets generated during and analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank Dr. Yeyin Xu for helpful comments.

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This work was supported by the National Natural Science Foundation of China (Grant Nos. 12132012 and 11972275).

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  1. State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi’an Jiaotong University, Xi’an, 710049, China

    Yangyang Yu, Zhixuan Yuan, Yongchen Fan & Ying Wu

  2. School of Information and Control Engineering, Xi’an University of Architecture and Technology, Xi’an, 710055, China

    Jiajia Li

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Yu, Y., Li, J., Yuan, Z. et al. Dynamic mechanism of epileptic seizures generation and propagation after ischemic stroke. Nonlinear Dyn 109, 3113–3132 (2022). https://doi.org/10.1007/s11071-022-07577-2

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