Abstract
Age-related cognitive declines are common and inevitable, but life trajectories of brain and cognitive functions are variable and plastic. To identify the mechanisms of decline, the prospects for improvement, and the constraints on the remedial approaches, the contributors of this special issuer examine several diverse areas of cognitive and brain aging: from structural and metabolic brain aging to genetics, and from age-sensitive cognitive domains to those that resist aging. In spite of such thematic diversity, several common threads are clear. To achieve better compensation for age-related changes in cognition, we need to understand their brain substrates, telling cognitively relevant from epiphenomenal. We also need to understand the sources of profound individual variability in aging trajectories, and to learn to tailor interventions to specific individual profiles of decline.
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Biondo-Simões, M. L., Matias, J. E., Montibeller, G. R., Siqueira, L. C., Nunes Eda, S., & Grassi, C. A. (2006). Effect of aging on liver regeneration in rats. Acta Cirurgica Brasileira, 21, 197–202.
Dahlin, E., Neely, A. S., Larsson, A., Bäckman, L., & Nyberg, L. (2008). Transfer of learning after updating training mediated by the striatum. Science, 320, 1510–1512.
Epstein, M. (1996). Aging and the kidney. Journal of the American Society of Nephrology, 7, 1106–1122.
Gould, E., Reeves, A. J., Fallah, M., et al. (1999). Hippocampal neurogenesis in adult Old World primates. Proceedings of the National Academy of Sciences of the United States of America, 96, 5263–5267.
Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. A., Cotman, C. W., & Sullivan, P. G. (2009). Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Experimental Neurology, 220, 171–176. Epub 2009 Aug 22.
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2009). Enrichment effects on adult cognitive development: Can the functional capacity of older adults be preserved and enhanced? Psychological Science in the Public Interest 1–65.
Horn, J. L. (1986). Intellectual stability concepts. In R. J. Steinberg (Ed.), Advances in psychology of human intelligence. Hillsdale: Erlbaum.
Ito, K., & Barnes, P. J. (2009). COPD as a disease of accelerated lung aging. Chest, 135, 173–180.
Joseph, J., Cole, G., Head, E., & Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. Journal of Neuroscience, 29, 12795–12801.
Lindenberger, U., & von Oertzen, T. (2006). Variability in cognitive aging: From taxonomy to theory. In E. Bialystok & F. I. M. Craik (Eds.), Lifespan cognition: Mechanisms of change (pp. 297–314). Oxford: Oxford University Press.
Lindenberger, U., Nagel, I. E., Chicherio, C., Li, S. C., Heekeren, H. R., & Bäckman, L. (2008). Age-related decline in brain resources modulates genetic effects on cognitive functioning. Frontier in Neuroscience, 2, 234–244. Epub 2008 Dec 15.
Park, D. C., & Reuter-Lorenz, P. (2009). The adaptive brain: aging and neurocognitive scaffolding. Annual Review of Psychology, 60, 173–196.
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., et al. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America, 104, 5638–5643. Epub 2007 Mar 20.
Raz, N. (2000). Ageing and the brain. In: Encyclopedia of life sciences, London: Nature Publishing Group, http://www.els.net/doi:10.1038/npg.els.0003375. October.
Raz, N., & Kennedy, K. M. (2009). A Systems approach to age-related change: Neuroanatomic changes, their modifiers, and cognitive correlates. In W. Jagust & M. D’Esposito (Eds.), Imaging the aging brain (pp. 43–70). New York: Oxford University Press.
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., et al. (2005). Regional brain changes in aging healthy adults: general trends, individual differences, and modifiers. Cerebral Cortex, 15, 1676–1689.
Raz, N., Dahle, C., Rodrigue, K. M., Kennedy, K. M., Land, S., & Jacobs, B. S. (2008). Brain-derived neurotrophic factor Val66Met polymorphism, blood glucose, and memory in healthy adults: the synergy of genetic and vascular risks. Frontiers in Human Neuroscience, 2, 12. Epub 2008 Oct 3.
Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE and hypertension. Neuropsychology, 23, 105–116.
Weinert, B. T., & Timiras, P. S. (2003). Physiology of aging. Invited review: theories of aging. Journal of Applied Physiology, 95, 1706–1716.
Wolf-Maier, K., Cooper, R. S., Banegas, J. R., Ciampaoli, S., Hense, H. W., Joffres, M., et al. (2003). Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA, 289, 2363–2369.
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Raz, N. Decline and Compensation in Aging Brain and Cognition: Promises and Constraints. Neuropsychol Rev 19, 411–414 (2009). https://doi.org/10.1007/s11065-009-9122-1
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DOI: https://doi.org/10.1007/s11065-009-9122-1