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Elucidating the Possible Role of FoxO in Depression

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Abstract

Forkhead box-O (FoxO) transcriptional factors perform essential functions in several physiological and biological processes. Recent studies have shown that FoxO is implicated in the pathophysiology of depression. Changes in the upstream mediators of FoxOs including brain-derived neurotrophic factor (BDNF) and protein kinase B have been associated with depressive disorder and the antidepressant agents are known to alter the phosphorylation of FoxOs. Moreover, FoxOs might be regulated by serotonin or noradrenaline signaling and the hypothalamic-pituitary-adrenal (HPA)-axis,both of them are associated with the development of the depressive disorder. FoxO also regulates neural morphology, synaptogenesis, and neurogenesis in the hippocampus, which accounts for the pathogenesis of the depressive disorder. The current article underlined the potential functions of FoxOs in the etiology of depressive disorder and formulate few essential proposals for further investigation. The review also proposes that FoxO and its signal pathway might establish possible therapeutic mediators for the management of depressive disorder.

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Acknowledgements

The authors would like to thank Chitkara University, Punjab, India for providing the basic facilities for the completion of the current article.

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  1. Tarapati Rana and Tapan Behl have contributed equally to this work.

Authors and Affiliations

  1. Chitkara College of Pharmacy, Chitkara University, Chandigarh, Punjab, India

    Tarapati Rana, Tapan Behl, Aayush Sehgal, Sukhbir Singh & Neelam Sharma

  2. Government Pharmacy College, Seraj, Mandi, Himachal Pradesh, India

    Tarapati Rana

  3. Government College of Pharmacy, Rohru, Distt., Shimla, Himachal Pradesh, India

    Vineet Mehta

  4. Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania

    Simona Bungau

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Rana, T., Behl, T., Sehgal, A. et al. Elucidating the Possible Role of FoxO in Depression. Neurochem Res 46, 2761–2775 (2021). https://doi.org/10.1007/s11064-021-03364-4

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  • DOI: https://doi.org/10.1007/s11064-021-03364-4

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