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Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment in Noise Stress Exposed Male Wistar Rats

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Abstract

Noise has always been an important environmental factor that induces health problems in the general population. Due to ever increasing noise pollution, humans are facing multiple auditory and non-auditory problems including neuropsychiatric disorders. In modern day life it is impossible to avoid noise due to the rapid industrialization of society. Continuous exposure to noise stress creates a disturbance in brain function which may lead to memory disorder. Therefore, it is necessary to find preventive measures to reduce the deleterious effects of noise exposure. Supplementation of taurine, a semi essential amino acid, is reported to alleviate psychiatric disorders. In this study noise-exposed (100 db; 3 h daily for 15 days) rats were supplemented with taurine at a dose of 100 mg/kg for 15 days. Spatial and recognition memory was assessed using the Morris water maze and novel object recognition task, respectively. Results of this study showed a reversal of noise-induced memory impairment in rats. The derangements of catecholaminergic and serotonergic levels in the hippocampus and altered brain antioxidant enzyme activity due to noise exposure were also restored by taurine administration. This study highlights the importance of taurine supplementation to mitigate noise-induced impaired memory via normalizing the neurochemical functions and reducing oxidative stress in rat brain.

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Abbreviations

5-HIAA:

5-Hydroxyindoleacetic acid

5-HT:

C5-hydroxytryptamine

AChE:

Acetylocholinesterase

CAT:

Catalase

DOPAC:

Dihydroxyphenylacetic acid

DA:

Dopamine

FST:

Force swim test

GPx:

Glutathione peroxidase

HPLC-EC:

High performance liquid chromatography with an electrochemical detector

LDT:

Light/dark transition test

LPO:

Lipid peroxidation

MDA:

Malondialdehyde

MWM:

Morris water maze

NA:

Nor-adrenaline

NOR:

Novel object recognition

SOD:

Superoxide dismutase

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Acknowledgements

Authors acknowledge the Dean Faculty of Science, University of Karachi, for providing the funds and facilities to conduct the experiment.

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Authors and Affiliations

  1. Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan

    Saida Haider, Irfan Sajid, Syeda Madiha, Sadia Sadir, Laraib Liaquat & Saiqa Tabassum

  2. Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan

    Irfan Sajid & Saima Khaliq

  3. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and BiologicalSciences, University of Karachi, Karachi, 75270, Pakistan

    Zehra Batool

  4. Department of Basic Medical Sciences, Faculty of Pharmacy, Barrett Hodgson University, Karachi, Pakistan

    Noor Kamil

  5. Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

    Saara Ahmad

  6. Department of Biochemistry, Shaheed Zuifiqar Ali Bhutto Institute of Science and Technology, Karachi, Pakistan

    Saiqa Tabassum

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  1. Saida Haider
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  2. Irfan Sajid
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Correspondence to Zehra Batool.

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Haider, S., Sajid, I., Batool, Z. et al. Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment in Noise Stress Exposed Male Wistar Rats. Neurochem Res 45, 2762–2774 (2020). https://doi.org/10.1007/s11064-020-03127-7

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  • DOI: https://doi.org/10.1007/s11064-020-03127-7

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