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Role of a Neural Cell Adhesion Molecule Found in Cerebrospinal Fluid as a Potential Biomarker for Epilepsy

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Abstract

The neural cell adhesion molecule (NCAM-1) plays an important role in cell adhesion and synaptic plasticity. We designed this study to evaluate NCAM-1 as a potential biomarker for epilepsy. We performed a quantitative evaluation of the levels of NCAM-1 in cerebrospinal fluid (CSF) and serum and noted differences in patients with epilepsy compared to control subjects. We used sandwich enzyme-linked immunosorbent assays to measure NCAM-1 concentrations in CSF and serum samples of 76 epileptic patients (subdivided into the following subgroups: drug-refractory epilepsy, DRE; first-diagnosis epilepsy, FDE; and drug-effective epilepsy, DEE) and 44 control subjects. Our results show that cerebrospinal fluid–NCAM-1 (CSF–NCAM-1) concentrations and NCAM-1 Indices in the epileptic group were lower than in the control group. Both the CSF–NCAM-1 concentration and the NCAM-1 Indices in the drug-refractory epilepsy group were lower than in the drug-effective epilepsy group. These differences were statistically significant (P < 0.05). However, serum–NCAM-1 levels were not statistically different when comparing the epilepsy group to the control group (P > 0.05). Our results indicate that CSF–NCAM-1 is a potential biomarker for drug-effective epilepsy and drug-refractory epilepsy.

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Acknowledgments

This work was supported by funds from the National Natural Science of China (No. 81071039). We thank the patients and their families for their participation in this study. We also sincerely thank the First Affiliated Hospital of Chongqing Medical University and the Affiliated Hospital of Guiyang Medical College for support and assistance in CSF and serum procurement.

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Authors and Affiliations

  1. Department of Neurology, The Affiliated Hospital of Guiyang Medical College, 28 Gui Yi Street, Guiyang, 550004, Guizhou Province, China

    Wei Wang & Lan Chu

  2. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing, 400016, China

    Liang Wang, Jing Luo, Zhiqin Xi, Xuefeng Wang & Guojun Chen

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  1. Wei Wang
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  2. Liang Wang
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  3. Jing Luo
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  7. Lan Chu
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Correspondence to Lan Chu.

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Wang, W., Wang, L., Luo, J. et al. Role of a Neural Cell Adhesion Molecule Found in Cerebrospinal Fluid as a Potential Biomarker for Epilepsy. Neurochem Res 37, 819–825 (2012). https://doi.org/10.1007/s11064-011-0677-x

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  • DOI: https://doi.org/10.1007/s11064-011-0677-x

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