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Expression of Matrix Metalloproteinase-9, Type IV Collagen and Vascular Endothelial Growth Factor in Adamantinous Craniopharyngioma

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Abstract

To explore the expression of matrix metalloproteinase 9 (MMP-9), type IV collagen (Col IV) and vascular endothelial growth factor (VEGF) in adamantinomatous craniopharyngioma (ACP) and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas recurrence. Expressions of MMP-9, Col IV and VEGF were tested by immunohistochemistry (IHC) in 40 cases of ACP, including 24 cases of primary group and 16 cases of recurred group. The expression level of MMP-9 and VEGF in recurred group were significantly higher than primary group (93.7% vs. 41.7%, P < 0.05, 87.5% vs. 45.8%, P < 0.05, respectively). The expression of Col IV in the recurred group was significant different from the primary group (Z = −2.619, P < 0.05). MMP-9, Col IV and VEGF may be the potential specific bio-marker related to the recurrence of ACP.

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Abbreviations

ACP:

Adamantimous craniopharyngiomas

AE:

Adamantine epithelioma

SCP:

Squamous cell papillary

MMP-9:

Matrix metalloproteinase-9

Col IV:

Type IV collagen

VEGF:

Vascular endothelial growth factor

IHC:

Immunohistochemistry

BM:

Basement membrane

ECM:

Extracellular matrix

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Acknowledgments

This project was supported by National Natural Funding, Beijing New Star of Technology Funding and Ningxia Natural Science Funding.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China

    Ge Jia, Yuqi Zhang, Chunde Li, Zhenyu Ma & Jian Gong

  2. Department of Neurosurgery, Ningxia Medical University, Ning Xia, China

    Wenqing Liu, Shengdong Li & Jihui Tian

  3. Department of Neurosurgery, Yulin Number 2 Hospital, Yulin, China

    Zhiqiang Xia

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  1. Zhiqiang Xia
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  2. Wenqing Liu
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  9. Jian Gong
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Correspondence to Jian Gong.

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Xia, Z., Liu, W., Li, S. et al. Expression of Matrix Metalloproteinase-9, Type IV Collagen and Vascular Endothelial Growth Factor in Adamantinous Craniopharyngioma. Neurochem Res 36, 2346–2351 (2011). https://doi.org/10.1007/s11064-011-0560-9

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  • DOI: https://doi.org/10.1007/s11064-011-0560-9

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