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IRBIT: It Is Everywhere

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Abstract

IRBIT (IP3Rs binding protein released with IP3) is a protein originally identified by the Mikoshiba group as an inhibitor of IP3 receptors function. Subsequently it was found to have multiple functions and regulate the activity of diverse proteins, including regulation of HCO3 − transporters to coordinate epithelial HCO3 − secretion and to determine localization of the Fip1 subunit of the CPSF complex to regulate mRNA processing. This review highlights the remarkably divers functions of IRBIT that are likely only a fraction of all the potential functions of this protein.

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  1. Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, Building 10, Room 1N-113, NIH, Bethesda, MD, 20892, USA

    Dongki Yang, Nikolay Shcheynikov & Shmuel Muallem

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  1. Dongki Yang
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  2. Nikolay Shcheynikov
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Correspondence to Shmuel Muallem.

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Special Issue: In Honor of Dr. Mikoshiba.

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Yang, D., Shcheynikov, N. & Muallem, S. IRBIT: It Is Everywhere. Neurochem Res 36, 1166–1174 (2011). https://doi.org/10.1007/s11064-010-0353-6

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