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Brain Oxidative Stress as Basic Target of Antioxidant Traditional Oriental Medicines

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Abstract

Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the psychologically induced oxidative stress, especially in the brain was supposed as one of the pathology of Mibyou. Several traditional herbal prescriptions applied for the brain disorder were found effective to prevent cerebral oxidative stress induced by ischemia/reperfusion and also under psychological distress produced by whiskers cut in mice. Shengmai San comprising three herbs, Panax ginseng, Ophiopogon japonicus and Schisandra chinensis is a traditional herbal medicine formula having a long history of using as a remedy and clinical prescription to treat coronal heart diseases. Multifunctional aspect of traditional herbal prescription was discussed in terms of preventing oxidative injury in the brain using Shengmai San as a typical prescription.

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References

  1. Halliwell B, Guteridge JMC (1985) Oxygnen toxicity, oxygen radicals, transition metals, and disease. Biochem J 21:1–14

    Google Scholar 

  2. Liu JK, Mori A (1999) Stress, aging, brain oxidative damage. Neurochem Res 24:1479–1497. doi:10.1023/A:1022597010078

    Article  PubMed  CAS  Google Scholar 

  3. Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA (2006) Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol 65:631–641. doi:10.1097/01.jnen.0000228136.58062.bf

    Article  PubMed  CAS  Google Scholar 

  4. Kidd PM (2008) Alzheimer disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Altern Med Rev 13:85–115

    PubMed  Google Scholar 

  5. Ebadi M, Sharma S (2006) Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease. Exp Biol Med 231:1576–1583

    CAS  Google Scholar 

  6. Danielson SR, Andersen K (2008) Oxidative and nitrative protein modifications in Parkinson’s disease. Free Radic Biol Med 44:1787–1794. doi:10.1016/j.freeradbiomed.2008.03.005

    Article  PubMed  CAS  Google Scholar 

  7. Fujimura M, Tominaga T, Chan PH (2005) Neuroprotective effect of an antioxidant in ischemic brain injury: involvement of neuronal apoptosis. Neurocrit Care 2:59–66. doi:10.1385/NCC:2:1:059

    Article  PubMed  CAS  Google Scholar 

  8. Mecocci P, Mariani E, Cornacchiola V, Polidori MC (2004) Antioxidants for the treatment of mild cognitive impairment. Neurol Res 26:598–602. doi:10.1179/016164104225017659

    Article  PubMed  CAS  Google Scholar 

  9. Kooncumchoo P, Sharma S, Porter J, Govitrapong P, Ebadi M (2006) Coenzyme Q10 provides neuroprotection in iron-induced apoptosis in dopaminergic neurons. J Mol Neurosci 28:125–142. doi:10.1385/JMN:28:2:125

    Article  PubMed  CAS  Google Scholar 

  10. Gonzalez-Perez O, Moy-Lopez NA, Guzman-Muniz J (2008) Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine. Rev Invest Clin 60:58–67

    PubMed  CAS  Google Scholar 

  11. Wei X, Ma Z, Fontanilla CV et al (2008) Caffeic acid phenethyl ester prevents cerebeller granule neurons (CGNs) against glutamate-induced neruotoxicity. Neuroscience 155:1098–1105. doi:10.1016/j.neuroscience.2008.06.056

    Article  PubMed  CAS  Google Scholar 

  12. Bordet R, Deplanque D, Maboudou P, Puisieux F et al (2000) Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance. J Cereb Blood Flow Metab 20:1190–1196. doi:10.1097/00004647-200008000-00004

    Article  PubMed  CAS  Google Scholar 

  13. Seif-El-Nasr M, Atia AS, Abdelsalam RM (2008) Effect MAO-B inhibition against ischemia-induced oxidative stress in the rat brain. Comparison with a rational antioxidant. Azrneimittelforschung 58:160–167

    CAS  Google Scholar 

  14. Watanabe T, Tahara M, Todo S (2008) The novel antioxidant edaravone; from bench to bedside. Cardiovasc Ther 26:101–114. doi:10.1111/j.1527-3466.2008.00041.x

    Article  PubMed  CAS  Google Scholar 

  15. Miyamoto R, Shimakawa S, Suzuki S, Ogihara T, Tamai H (2008) Edaravone prevents kainic acid-induced neuronal death. Brain Res 1209:85–91. doi:10.1016/j.brainres.2008.02.064

    Article  PubMed  CAS  Google Scholar 

  16. Chacon JN, Chedekel MR, Land EJ, Truscott TG (1987) Chemically induced Parkinson’s disease: intermediates in the oxidation of 1-methyl-4-phenylpyridinium ion. Biochem Biophys Res Commun 144:957–964. doi:10.1016/S0006-291X(87)80057-8

    Article  PubMed  CAS  Google Scholar 

  17. Halliwell B, Gutteridge JMC (1985) Oxygen radicals and the nervous system. Trends Neurosci 8:22–26. doi:10.1016/0166-2236(85)90010-4

    Article  CAS  Google Scholar 

  18. Ebadi M, Sharma S (2003) Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson’s disease. Antioxid Redox Signal 5:319–335. doi:10.1089/152308603322110896

    Article  PubMed  CAS  Google Scholar 

  19. Bubber P, Haroutunian V, Fisch G et al (2005) Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol 57:695–703. doi:10.1002/ana.20474

    Article  PubMed  CAS  Google Scholar 

  20. Plaas M, Karis A, Innos J et al (2008) Alpha-synuclein A30P point-mutaiton generates age-dependent nigrostariatal deficiency in mice. J Physiol Pharmacol 59:205–216

    PubMed  CAS  Google Scholar 

  21. Chiueh CC, Andoh T, Lai AR, Lai E, Krishna G (2000) Neuroprotective strategies in Parkinson’s disease: protection against progression nigral damage induced by free radical. Neurotox Res 2:293–310

    PubMed  CAS  Google Scholar 

  22. Cheng JT (2000) Drug therapy in Chinese traditional medicine. J Clin Pharmacol 40:445–450. doi:10.1177/00912700022009198

    Article  PubMed  CAS  Google Scholar 

  23. Zhang E (ed) (1988) Basic theory of traditional Chinese medicine. Publishing House of Shanghai University of Traditional Chinese Medicine, China

    Google Scholar 

  24. Konishi T, Ichikawa H, Nishida H, Wang XJ (2006) Protection of oxidative brain injury by Chinese herbal medicine. In: Packer L, Hiramatsu M, Yoshikawa T (eds) Herbal medicine & molecular basis in health and disease management. Marcel Dekker, NY, pp 635–642

    Google Scholar 

  25. Ou B, Huang D, Hampsch-woodill M, Flanagan JA (2003) When east meets west: the relationship between yin-yang and antioxidation-oxidation. FASB J 17:127–129. doi:10.1096/fj.02-0527hyp

    Article  CAS  Google Scholar 

  26. Adams M, Gmunder F, Hamburger M (2007) Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature. J Ethnopharmacol 113:363–381. doi:10.1016/j.jep.2007.07.016

    Article  PubMed  Google Scholar 

  27. Iwasaki K, Satoh-Nakagawa T, maruyama M et al (2005) A Randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral an psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry 66:248–252

    Article  PubMed  Google Scholar 

  28. Liu JK, Edamatsu R, Kabuto H, Mori A (1990) Antioxidant action of Guilingji in the brain of rats with FeCl3-induced epilepsy. Free Radic Biol Med 9:451–454. doi:10.1016/0891-5849(90)90023-C

    Article  PubMed  CAS  Google Scholar 

  29. Liang SM, Chen SY, Kian SQ (2002) Shengmai San––a renowned traditional Chinese medicinal formula. In: Ko KM (ed) Shengmai San. Taylor & Francis, London, pp 1–15

    Google Scholar 

  30. Wang XJ, Ichikawa H, Konishi T (2001) Antioxidant potential of Qizhu Tang, a Chinese herbal medicine, and the effect on cerebral oxidative damage after ischemia-reperfusion in rat. Biol Pharm Bull 24:558–563. doi:10.1248/bpb.24.159

    Article  Google Scholar 

  31. Kraus RS, Pasieczny R, Lariosa-Willingham K et al (2005) Antioxidant properties of minocyclin; neuroprotection in an oxidative stress assay and direct radical-scavenging assay. J Neurochem 94:819–827. doi:10.1111/j.1471-4159.2005.03219.x

    Article  PubMed  CAS  Google Scholar 

  32. Rausch WD, Liu S, Gille G, Radad K (2006) Neuroprotective effects of ginsenosides. Acta Neurobiol Exp 66:369–375

    Google Scholar 

  33. Tang SY, Whiteman M, Peng ZF, Jenner A, Young EL, Halliwell B (2004) Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional Chinese medicines. Free Radic Biol Med 36:1575–1587. doi:10.1016/j.freeradbiomed.2004.03.017

    Article  PubMed  CAS  Google Scholar 

  34. Wang XJ, Magara T, Konishi T (1999) Prevention and repair of cerebral ischemia-reperfusion injury by Chinese herbal medicine, Shengmai San, in rats. Free Radic Res 31:449–455. doi:10.1080/10715769900301011

    Article  Google Scholar 

  35. Ichikawa H, Konishi T (2002) In vitro antioxidant potentials of traditional Chinese medicine, Shengmai San and their relation to in vivo protective effect on cerebral oxidative damage in rats. Biol Pharm Bull 25:898–903. doi:10.1248/bpb.25.898

    Article  PubMed  CAS  Google Scholar 

  36. Ichikawa h Wang HJ, Konishi T (2002) Role of component herbs in antioxidant activity of Shengmai San, a traditional Chinese medicine formula preventing cerebral oxidative damage in rat. Am J Chin Med 31:509–521

    Google Scholar 

  37. Wang L, Nishida H, Ogawa Y, Konishi T (2003) Prevention of oxidative injury in PC12 cells by a traditional Chinese medicine, Shengmai San, as a model of an antioxidant-based composite formula. Biol Pharm Bull 26:1000–1004. doi:10.1248/bpb.26.1000

    Article  PubMed  CAS  Google Scholar 

  38. Ichikawa H, Wang L, Konishi T (2006) Prevention of cerebral oxidative injury by post-ischemic intravenous administration of Shengmai San. Am J Chin Med 34:591–600. doi:10.1142/S0192415X06004120

    Article  PubMed  Google Scholar 

  39. Konishi T, Li YJ, Nishida H, Gong M (2005) Modulation of antioxidant gene expression by TCM in mentally stressed mice as a model of sub-healthy condition. MEDIMOND Int Proc of ISNA & SFRR, Asia, pp 79–85

    Google Scholar 

  40. Motoshima T, Sato S, Konishi T (2007) The effect of Zokumei-to on cerebral oxidative stress model in rats and mice. Pharmacometrics 72:57–62

    Google Scholar 

  41. Chen N, Chu PY, Ko KM (2008) Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats. Biol Pharm Bull 31:1387–1391. doi:10.1248/bpb.31.1387

    Article  PubMed  CAS  Google Scholar 

  42. Li YJ, Gong M, Konishi T (2007) Antioxidant Synergism among Component Herbs of Traditional Chinese Medicine Hormula, Shengmai San Studied in vitro and in vivo. J Health Sci 53:692–699. doi:10.1248/jhs.53.692

    Article  Google Scholar 

  43. Wang Q (2001) Traditional Chinese medicine will make new contributions to mankind in treating sub-healthy conditions in the 21 century. J Beijing Univ TCM 24:1–4

    CAS  Google Scholar 

  44. Bultz BD, Carlson LE (2005) Emotional distress: the sixth vital sign in cancer care. J Clin Oncol 23:6440–6441. doi:10.1200/JCO.2005.02.3259

    Article  PubMed  Google Scholar 

  45. Liu JK, Wang XY, Shigenaga MK, Yeo HC, Mori A (1996) Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rat. FASEB J 10:1532–1538

    PubMed  CAS  Google Scholar 

  46. Wang L, Muxin G, Nishida H, Shirakawa C, Sato S, Konishi T (2006) Psychological stress-induced oxidative stress as a model of sub-healthy condition and the effect of TCM. eCAM 4:195–202

    PubMed  Google Scholar 

  47. Talwar SK, Xu S, Hawley ES, Weiss S, Moxon KA, Chapin JK (2002) Rat navigation guided by remote control. Nature 417:37–38. doi:10.1038/417037a

    Article  PubMed  CAS  Google Scholar 

  48. Rahman MM, Ichiyanagi T, Komiyama T, Sato S, Konishi T (2008) Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status. J Agric Food Chem 56:7545–7550

    Article  PubMed  CAS  Google Scholar 

  49. Nishida H, Kushida M, Nakajima Y, Ogawa Y, Tatewaki N, Konishi T (2007) Amyloid-b-induced cytotoxicity of PC-12 cell was attenuated by Shengmai San through redox regulation and outgrowth induction. J Pharmacol Sci 104:73–81. doi:10.1254/jphs.FP0070100

    Article  PubMed  CAS  Google Scholar 

  50. Wang NL, Liou YL, Lin MT, Lin CL, Chang CK (2005) Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J Pharmacol Sci 97:253–265. doi:10.1254/jphs.FP0040793

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Functional and Analytical Food Sciences, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), Higashijima 265-1 Akiha-Ku, Niigata, 956-8603, Japan

    Tetsuya Konishi

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  1. Tetsuya Konishi
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Correspondence to Tetsuya Konishi.

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Special issue article in honor of Dr. Akitane Mori.

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Konishi, T. Brain Oxidative Stress as Basic Target of Antioxidant Traditional Oriental Medicines. Neurochem Res 34, 711–716 (2009). https://doi.org/10.1007/s11064-008-9872-9

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