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The Functional Regulation of TRPV1 and Its Role in Pain Sensitization

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Abstract

Transient receptor potential V1 (TRPV1) is specifically expressed in the nociceptive receptors and can detect a variety of noxious stimuli, thus potentiating pain sensitization. While peripheral delivery of capsaicin causes the desensitization of sensory neurons, thus alleviating pain. Therefore capsaicin is used in the clinical treatment of various types of pain; however, these treatments will bring many side effects, such as a strong burning pain in the early stages of treatment which hampers the further use of capsaicin. Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity. Thus we would summarize the progress of these two aspects in this mini review.

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Acknowledgments

All the works were supported by grants from the National Natural Science Foundation of China (30371635, 303330230 and 30770703), a grant from the Beijing Natural Science Foundation (7072040), and a grant from the specialized Research Fund for Doctoral Program of Higher Education (20060001121).

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  1. Department of Neurobiology, Key Laboratory for Neuroscience of Ministry of Education and Health, Neuroscience Research Institute, Peking University, Beijing, 100083, People’s Republic of China

    Yun Wang

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Correspondence to Yun Wang.

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Special issue article in honor of Dr. Ji-Sheng Han.

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Wang, Y. The Functional Regulation of TRPV1 and Its Role in Pain Sensitization. Neurochem Res 33, 2008–2012 (2008). https://doi.org/10.1007/s11064-008-9750-5

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