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α4β2-Nicotinic Receptor Binding with 5-IA in Alzheimer’s Disease: Methods of Scan Analysis

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Abstract

Five patients with Alzheimer’s disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand 123I-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen’s d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer’s disease.

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Acknowledgements

This work was supported by the Gordon Small Charitable Trust and the European Commission Network of Excellence "Diagnostic Molecular Imaging" (FP6-LIFESCIHEALTH Project Reference: 512146).

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Authors and Affiliations

  1. Division of Psychiatry, University of Edinburgh, Edinburgh, UK

    Emma Terrière, Mike Sharman, Claire Donaghey, Lucie Herrmann, Jane Lonie, Marion Strachan, Nadine Dougall, Jonathan Best & Klaus P. Ebmeier

  2. Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK

    Lucie Herrmann & Klaus P. Ebmeier

  3. Department of Medical Physics and West of Scotland Radionuclide Pharmacy, Southern General Hospital, Glasgow, UK

    Sally Pimlott, Jim Patterson & David Wyper

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  1. Emma Terrière
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  2. Mike Sharman
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  3. Claire Donaghey
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  4. Lucie Herrmann
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  5. Jane Lonie
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  9. Klaus P. Ebmeier
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Correspondence to Klaus P. Ebmeier.

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Special issue article in honor of George Fink.

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Terrière, E., Sharman, M., Donaghey, C. et al. α4β2-Nicotinic Receptor Binding with 5-IA in Alzheimer’s Disease: Methods of Scan Analysis. Neurochem Res 33, 643–651 (2008). https://doi.org/10.1007/s11064-007-9517-4

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  • DOI: https://doi.org/10.1007/s11064-007-9517-4

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