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Effects of Chronic Haloperidol and/or Clozapine on Oxidative Stress Parameters in Rat Brain

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Abstract

Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine whether CLO for 28 days could reverse or attenuate HAL-induced oxidative damage in animals previously treated with HAL for 28 days. HAL significantly increased thiobarbituric acid reactive substances levels in the cortex (CX) and striatum and increased protein carbonyls in hippocampus (HP) and CX and this was not attenuated by CLO treatment. In the total radical trapping antioxidant parameter assay there was a decrease in the HP total antioxidant potential induced by HAL and by treatment with HAL + CLO. Our findings demonstrated that the atypical antipsychotic CLO could not revert oxidative damage caused by HAL.

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Acknowledgments

This work was supported by grants from CNPq, FAPESC, Instituto Cérebro e Mente and UNESC (Brazil).

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Authors and Affiliations

  1. Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciuma, Santa Catarina, Brazil

    Fabiano R. Agostinho, Luciano K. Jornada & João Quevedo

  2. Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University, 90619-900, Porto Alegre, Rio Grande do Sul, Brazil

    Nadja Schröder

  3. Department of Pharmacology, Institute for Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90046-900, Porto Alegre, Rio Grande do Sul, Brazil

    Rafael Roesler

  4. Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciuma, Santa Catarina, Brazil

    Felipe Dal-Pizzol

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  1. Fabiano R. Agostinho
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  2. Luciano K. Jornada
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Correspondence to João Quevedo.

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Agostinho, F.R., Jornada, L.K., Schröder, N. et al. Effects of Chronic Haloperidol and/or Clozapine on Oxidative Stress Parameters in Rat Brain. Neurochem Res 32, 1343–1350 (2007). https://doi.org/10.1007/s11064-007-9311-3

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  • DOI: https://doi.org/10.1007/s11064-007-9311-3

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