Abstract
The antioxidant capabilities of phosphatidylethanolamine plasmalogen (PlsEtn), in vivo, against lipid peroxidation were investigated via acute phosphine (PH3) administration in rats. Oxidative stress was assessed from measures of malondialdehyde and various enzyme activities, while NMR analyses of lipid and aqueous tissue extracts provided metabolic information in cerebellum, brainstem, and cortex. Brainstem had the highest basal [PlsEtn], and showed only moderate PH3-induced oxidative damage with no loss of ATP. The lowest basal [PlsEtn] was observed in cortex, where PH3 caused a 51% decrease in [ATP]. The largest oxidative effect occurred in cerebellum, but [ATP] was unaffected. Myo-inositol+ethanolamine pretreatment attenuated all PH3 effects. Specifically, the pretreatment attenuated the ATP decrease in cortex, and elevated brain [PlsEtn] in the cerebellum, nearly abolishing the cerebellar oxidative effects. Our data suggest a high basal [PlsEtn], or the capacity to synthesize new ethanolamine lipids (particularly PlsEtn) may protect against PH3 toxicity.
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Kuczynski, B., Reo, N.V. Evidence that Plasmalogen is Protective Against Oxidative Stress in the Rat Brain. Neurochem Res 31, 639–656 (2006). https://doi.org/10.1007/s11064-006-9061-7
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DOI: https://doi.org/10.1007/s11064-006-9061-7