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Neuropathic Pain Modifies Antioxidant Activity in Rat Spinal Cord

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Abstract

Oxidative stress is an important pathophysiological mechanism of many neurological diseases. Reactive oxygen and nitrogen species have been cited as molecules involved in the nociceptive process. In this study, rats were submitted to sciatic nerve transection (SNT) for induction of neuropathic pain, and enzyme activities of SOD and catalase as well as lipid peroxidation (LPO) were measured in the lumbosacral spinal cord. The results show that LPO was not changed after SNT. SOD activity was reduced 7 days after SNT, while the change in catalase activity occurred on the third and seventh days in both sham and SNT animals. Hyperalgesia in SNT group was detected at the same points in time. These results suggest that SNT was not a strong enough stimulus to deplete all antioxidant content in the spinal cord, since increase in LPO was not detected. However, the role of oxidative stress in nociception can not be excluded.

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Acknowledgements

This work was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS).

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Authors and Affiliations

  1. Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brasil

    Renata P. Guedes, Lidiane Dal Bosco, Camila M. Teixeira, Alex S. R. Araújo, Adriane Belló-Klein, Maria Flávia M. Ribeiro & Wania A. Partata

  2. Instituto de Bioquímica e Biofísica, Faculdade de Farmácia e Bioquímica, Universidade de Buenos Aires, Buenos Aires, Argentina

    Susana Llesuy

  3. Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, UFRGS, Rua Sarmento Leite, 500, 90050-170, Porto Alegre, RS, Brazil

    Wania A. Partata

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  1. Renata P. Guedes
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  2. Lidiane Dal Bosco
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  3. Camila M. Teixeira
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  4. Alex S. R. Araújo
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  6. Adriane Belló-Klein
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  7. Maria Flávia M. Ribeiro
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  8. Wania A. Partata
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Correspondence to Wania A. Partata.

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Guedes, R.P., Bosco, L.D., Teixeira, C.M. et al. Neuropathic Pain Modifies Antioxidant Activity in Rat Spinal Cord. Neurochem Res 31, 603–609 (2006). https://doi.org/10.1007/s11064-006-9058-2

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  • DOI: https://doi.org/10.1007/s11064-006-9058-2

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