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Decrease of Serotonin Transporters in Blood Platelets after Epileptic Seizures

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Abstract

Serotonin transporter (SERT) was studied by [3H]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average KD and BMax were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.

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Authors and Affiliations

  1. Istituto di Bioimmagini e Fisiologia Molecolare, CNR Sezione di Genova, Italy

    Aroldo Cupello & Simona Scarrone

  2. Dipartimento di Neuroscienze, Oftalmologia e Genetica, Facoltà di Medicina, Università di Genova, Italy

    Emilio Favale, Daniela Audenino, Stefania Gastaldi & Claudio Albano

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  1. Aroldo Cupello
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  2. Emilio Favale
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  3. Daniela Audenino
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  4. Simona Scarrone
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  5. Stefania Gastaldi
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  6. Claudio Albano
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Correspondence to Aroldo Cupello.

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Cupello, A., Favale, E., Audenino, D. et al. Decrease of Serotonin Transporters in Blood Platelets after Epileptic Seizures. Neurochem Res 30, 425–428 (2005). https://doi.org/10.1007/s11064-005-2676-2

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  • DOI: https://doi.org/10.1007/s11064-005-2676-2

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