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Allergic conditions and risk of glioma and meningioma in the CERENAT case-control study

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Abstract

Inverse association between allergic conditions and glioma risk has been consistently reported in epidemiological studies with little attention paid to potential environmental confounders; the association with meningioma risk is less consistent. We examined the association between allergy history and risk of glioma and meningioma in adults using data from the CERENAT (CEREbral tumors: a NATional study) multicenter case-control study carried out in 4 areas in France in 2004–2010. Participants’ histories of doctor-diagnosed allergic asthma, eczema, rhinitis/hay fever and other allergic conditions were collected at onset through a detailed questionnaire delivered in a face-to-face interview. Conditional logistic regression for matched sets was adjusted for participants’ educational level and mobile phone use. A total of 273 glioma cases, 218 meningioma cases and 982 matched controls selected from the local electoral rolls were analyzed. A significant inverse association was found between glioma and a history of any allergy (OR 0.52, 95% CI 0.36–0.75), with a dose–effect relationship with the number of allergic conditions reported (p-trend = 0.001) and a particularly strong association with hay fever/allergic rhinitis (OR 0.46, 95% CI 0.30–0.72). Interestingly, associations with glioma risk were more pronounced in women. For meningioma, no association was observed with overall or specific allergic conditions. Our findings confirmed the inverse association between allergic conditions and glioma risk but questioned the role of allergy in meningioma risk. Future research is needed to clarify the biological mechanism of overall allergy and allergic rhinitis on glioma and to confirm the different effect by gender.

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Acknowledgements

We thank the interviewers of CERENAT study: Christine Auguin, Gaëtane Blaizot, Anne-Sophie Lacauve, Elodie Niez, Xavier Schwall and Sandrine Schwall. We also thank Anne Jaffré and Véronique Loyant for their invaluable contribution to the study. The CERENAT study received funding from the following French public research agencies: French National Institute of Health and Medical Research (INSERM), the French agency for Food, Environmental and Occupational Health Safety (ANSES), French Cancer Research Association (ARC - réseau ARECA) and the French League against Cancer (Ligue contre le Cancer - Comité Aquitaine Charentes).

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Authors and Affiliations

  1. Université de Bordeaux, INSERM, Bordeaux Population Health Research Center, Team EPICENE, UMR 1219, 146, rue Léo Saignat, 33076, Bordeaux Cedex, France

    Camille Pouchieu, Chantal Raherison, Clément Piel, Lucile Migault, Camille Carles & Isabelle Baldi

  2. CHU de Bordeaux, Service de Pneumologie, 33076, Bordeaux Cedex, France

    Chantal Raherison

  3. CHU de Bordeaux, Service de Médecine du Travail, 33076, Bordeaux Cedex, France

    Camille Carles & Isabelle Baldi

  4. Unité de Biostatistiques Epidémiologie, Institut Universitaire de Recherche Clinique, Université de Montpellier I, 34093, Montpellier Cedex, France

    Pascale Fabbro-Perray

  5. BESPIM, CHU de Nîmes, 30029, Nîmes Cedex, France

    Pascale Fabbro-Perray

  6. CHU de Bordeaux, Service de Neurochirurgie A, 33076, Bordeaux Cedex, France

    Hugues Loiseau

  7. Département de Neurologie, CHU de Caen, Caen, France

    Jean-Sébastien Guillamo

  8. INSERM, UMR 1086 ANTICIPE, Université de Caen Normandie, 14000, Caen, France

    Pierre Lebailly

  9. Centre de Lutte Contre le Cancer François Baclesse, 14076, Caen Cedex 05, France

    Pierre Lebailly

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  1. Camille Pouchieu
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Correspondence to Camille Pouchieu.

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Pouchieu, C., Raherison, C., Piel, C. et al. Allergic conditions and risk of glioma and meningioma in the CERENAT case-control study. J Neurooncol 138, 271–281 (2018). https://doi.org/10.1007/s11060-018-2816-6

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