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Recovery of empathetic function following resection of insular gliomas

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Abstract

The insular cortex is located deep within the Sylvian fissure between multi-functional and structurally-compressed cerebral structures, and has been suggested to play an important role in both basic sensorimotor and complex social-emotional functions. Such structural and functional complexity presents a challenge for neurosurgeons to remove tumors within the insula safely. It has therefore not yet been documented how neurosurgical resection of insular gliomas would impact social-emotional functions. In this study, we examined empathy, a high-level social-emotional function, in four patients with localized insular gliomas pre- and post-operatively. The patients completed an empathy-for others pain task in which they viewed another person’s hand or foot in painful or non-painful situations and made judgments about either pain (explicit empathy) or laterality of the hand or foot (implicit empathy). They also completed questionnaires assessing general emotional processing and personality. Deficits in both explicit and implicit empathetic pain processing were found in patients before the operations. However, the operations significantly improved their empathetic ability after surgery, accompanied by unchanged personality traits. These results confirmed previous findings that the insula plays a critical role for empathetic pain perception. Importantly, the current results suggest that surgical resection is not only a suitable treatment for insular gliomas for clinical consideration, but also effective in improving high-level functions such as empathetic pain perception.

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Acknowledgments

This research was supported by National Science and Technology Support Program of the 12th 5-year of China (Grant Number: 2012BAI12B03) to P. L, by Natural Science Foundation of Beijing (Grant Number: 7112049) to P. L and by National Science Foundation of China (Grant Number: 81328008) to J. F and Z. G. J. F was supported by National Institute of Health (NIH) Grants R21MH083164. P. R. H was supported by The James S. McDonnell Foundation (Grant 22002078).

Conflict of interest

The authors declare they have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    Xingchao Wang, Shiwei Wang, Pinan Liu & Zhixian Gao

  2. Wellcome Trust Centre for Neuroimaging, University College London, London, WC1N 3BG, UK

    Xiaosi Gu

  3. Virginia Tech Carilion Research Institute, Roanoke, VA, 24016, USA

    Xiaosi Gu

  4. Department of Psychology, Queens College, The City University of New York, Flushing, NY, 11367, USA

    Jin Fan

  5. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Jin Fan

  6. Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Jin Fan & Patrick R. Hof

  7. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Jin Fan & Patrick R. Hof

  8. Department of Neural Reconstruction, Beijing Neurosurgery Institute, Capital Medical University, Beijing, 100050, China

    Fu Zhao & Pinan Liu

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  1. Xingchao Wang
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Correspondence to Pinan Liu or Zhixian Gao.

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Wang, X., Gu, X., Fan, J. et al. Recovery of empathetic function following resection of insular gliomas. J Neurooncol 117, 269–277 (2014). https://doi.org/10.1007/s11060-014-1380-y

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  • DOI: https://doi.org/10.1007/s11060-014-1380-y

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