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Role of surgery, radiotherapy and chemotherapy in papillary tumors of the pineal region: a multicenter study

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Abstract

Papillary tumor of the pineal region (PTPR), recently described as a distinct clinicopathological entity, can show aggressive biological behavior. The optimal therapeutic approach of PTPR has not been well defined. The role of surgery, radiotherapy, and chemotherapy in the treatment of PTPR was analyzed in a large multicenter series. In order to determine factors that influence prognosis, outcome data of a series of 44 patients with histopathologically proven PTPR were retrospectively analyzed. Of the 44 patients, 32 were still alive after a median follow-up of 63.1 months. Twelve patients experienced progressive disease, with seven undergoing two relapses and five more than two. Median overall survival (OS) was not achieved. Median progression-free survival (PFS) was 58.1 months. Only gross total resection and younger age were associated with a longer OS, radiotherapy and chemotherapy having no significant impact. PFS was not influenced by gross total resection. Radiotherapy and chemotherapy had no significant effect. This retrospective series confirms the high risk of recurrence in PTPR and emphasizes the importance of gross total resection. However, our data provide no evidence for a role of adjuvant radiotherapy or chemotherapy in the treatment of PTPR.

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Acknowledgments

We thank the pathologists H. Adle Biassette (Créteil), C. Bouvier (Marseille), F. Chrétien (Créteil), C. Christov (Créteil), N. Costes-Charlet (Clermont-Ferrand), C. Daumas-Duport (Paris), M.B. Delisle (Toulouse), C. Fernandez (Marseille), R. Gherardi (Créteil), J.M. Goujon (Poitiers), B. Grignon (Nancy), A. Heitzmann (Orléans), D. Henin (Paris), J.L. Kemeny (Clermont-Ferrand), N. Kopp (Lyon), K. Kuchelmeister (Giessen), M. Kujas (Paris), A. Lellouch-Tubiana (Paris), J.F. Michiels (Nice), J. Mikol (Paris), N. Streichenberger (Lyon), M. Yver (Poitiers); the neurosurgeons B. Bataille (Poitiers), H. Boissonnet (Paris), P. Bousquet (Toulouse), P. Bret (Lyon), S. Clemenceau (Paris), P. Decq (Créteil), H. Dufour (Marseille), G. Fisher (Lyon), S. Fuentes (Marseille), T. Inoue (Sendai), B. Irthum (Clermont-Ferrand), P. Kauffmann (Clermont-Ferrand), M. Kalamarides (Paris), A. Morita (Tokyo), B. Muckensturm (Orléans), I. Pelissou-Guyotat (Lyon), J. Remond (Lyon), C. Sainte-Rose (Paris), M. Samii (Hannover), and M. Sindou (Lyon); the neuro-oncologists L. Taillandier (Nancy), M. Frenay (Nice), O. Chinot (Marseille), J. Honnorat (Lyon), B. Wrede (Regensburg), and J.E. Wolff (Regensburg); the radiotherapists M. Benhassel (Rennes), R.J. Bensadoun (Poitiers), P.Y. Bondiau (Nice), S. Hoffstetter (Nancy), J.J. Mazeron (Paris), F. Mornex (Lyon), and M. Schlienger (Paris); E. Chamorey (Nice) for statistical anlysis and T. Barkas for linguistic help.This work was supported by the association ADeRTU and INSERM.

Ethical standards

The present experiments comply with the current laws of the countries in which they were performed.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Centre de Haute Energie, Centre de Radiothérapie Privé and ADeRTU, Nice, France

    F. Fauchon

  2. Institute of Neuropathology, University Hospital Munster, Munster, Germany

    M. Hasselblatt

  3. Service de Pathologie et de Neuropathologie, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Lyon, France

    A. Jouvet & A. Vasiljevic

  4. Equipe Neuro-Oncologie et Neuro-Inflammation, Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, Université de Lyon, 69372, Lyon, France

    A. Jouvet, J. Champier & M. Fèvre Montange

  5. Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    M. Popovic

  6. Neurosurgery, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK

    R. Kirollos & T. Santarius

  7. Department of Radiology, University of Tokyo, Tokyo, Japan

    S. Amemiya

  8. Department of Neurosurgery, Tohoku University, Sendai, Japan

    T. Kumabe

  9. Département d’Oncologie Pédiatrique, Centre Léon Bérard, Lyon, France

    D. Frappaz

  10. Service de Neurochirurgie, Hôpital Pasteur, Nice, France

    M. Lonjon

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  1. F. Fauchon
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  2. M. Hasselblatt
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  3. A. Jouvet
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  4. J. Champier
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  5. M. Popovic
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  6. R. Kirollos
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  7. T. Santarius
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  8. S. Amemiya
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  9. T. Kumabe
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  10. D. Frappaz
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  11. M. Lonjon
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  12. M. Fèvre Montange
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  13. A. Vasiljevic
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Corresponding author

Correspondence to M. Fèvre Montange.

Additional information

F. Fauchon, M. Hasselblatt, M. Fèvre Montange and A. Vasiljevic contributed equally to this study.

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Fauchon, F., Hasselblatt, M., Jouvet, A. et al. Role of surgery, radiotherapy and chemotherapy in papillary tumors of the pineal region: a multicenter study. J Neurooncol 112, 223–231 (2013). https://doi.org/10.1007/s11060-013-1050-5

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