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MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression

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Abstract

MicroRNAs (miRNAs), small non-protein-coding RNA molecules, modulate target gene expression by binding to 3′untranslated regions (UTR) of target mRNA. These molecules are aberrantly expressed in many human cancers, and can function either as tumor suppressors or oncogenes. In the current study, we show that miR-107 is down-regulated in glioma tissues and cell lines, and its overexpression leads to inhibition of the migratory and invasive ability of glioma cells via direct targeting of Notch2, which is known to transactivate Tenascin-C and Cox-2. Experiments with Notch2 siRNA further suggest that miR-107 may exerts its anti-invasive activity through Notch2 signaling pathways. Our findings collectively indicate that miR-107 is involved in glioma cell migration and invasion, and support its utility as a potential target for glioma treatment.

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Acknowledgments

This work was supported by grants from the funds for National Key Clinic Department, the Natural Science Fund of China (No. 81171179), the Natural Science Fund of China (No. 81272439), the Funds for Key Sci-Tech Research Projects of Guangdong (No. 2008A030201019) and Guangzhou (No. 09B52120112-2009J1-C418-2, No. 2008A1-E4011-6) to Professor Xiaodan Jiang.

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No conflicts of interest were declared.

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Authors and Affiliations

  1. The National Key Clinic Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, 253# Gongye Road, Guangzhou, 510282, China

    Lei Chen, Run Zhang, Peng Li, Yi Liu, Ke Yan & Xiao-Dan Jiang

  2. Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China

    Xiang-Rong Chen

  3. Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, 362000, China

    Xiang-Rong Chen

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  1. Lei Chen
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  2. Xiang-Rong Chen
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  3. Run Zhang
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  4. Peng Li
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  5. Yi Liu
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  6. Ke Yan
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  7. Xiao-Dan Jiang
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Corresponding author

Correspondence to Xiao-Dan Jiang.

Additional information

Lei Chen and Xiang-Rong Chen contributed equally to this work.

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Chen, L., Chen, XR., Zhang, R. et al. MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression. J Neurooncol 112, 59–66 (2013). https://doi.org/10.1007/s11060-012-1037-7

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  • DOI: https://doi.org/10.1007/s11060-012-1037-7

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