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Sporadic primary malignant intracerebral nerve sheath tumors: case report and literature review

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Abstract

We report the case of a seventy-five year old woman with a sporadic primary malignant intracerebral nerve sheath tumor (MINST). These tumors fall within the spectrum of malignant peripheral nerve sheath tumors (MPNST) but confirming the diagnosis of a MINST can be difficult due to its rarity and unusual intraparenchymal location. Radiographically, MINST’s mimic malignant glioma and should be considered in the differential diagnosis of enhancing cerebral lesions. In this report, we present a comprehensive panel of histological, immunohistochemical, ultrastructural, and genetic considerations that may be used to diagnosis MINST based on their similarities to MPNSTs and brain parenchyma location.

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Authors and Affiliations

  1. Department of Surgery (Neurosurgery), Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Zachary Rollins Barnard, Pankaj Kumar Agarwalla, Deva Sanjeeva Jeyaretna, Christopher James Farrell & William Thomas Curry Jr.

  2. Department of Surgery (Neurosurgery), Massachusetts General Hospital, 55 Fruit St, Yawkey 9E, Boston, MA, 02114, USA

    Zachary Rollins Barnard

  3. Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, 55 Fruit St, Yawkey 9E, Boston, MA, 02114, USA

    Elizabeth Robins Gerstner & William Thomas Curry Jr.

  4. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Elizabeth Robins Gerstner

  5. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Di Tian

Authors
  1. Zachary Rollins Barnard
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  2. Pankaj Kumar Agarwalla
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  3. Deva Sanjeeva Jeyaretna
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  4. Christopher James Farrell
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  5. Elizabeth Robins Gerstner
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  6. Di Tian
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  7. William Thomas Curry Jr.
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Correspondence to Zachary Rollins Barnard.

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Barnard, Z.R., Agarwalla, P.K., Jeyaretna, D.S. et al. Sporadic primary malignant intracerebral nerve sheath tumors: case report and literature review. J Neurooncol 104, 605–610 (2011). https://doi.org/10.1007/s11060-011-0531-7

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  • DOI: https://doi.org/10.1007/s11060-011-0531-7

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