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Fractionated radiotherapy for intracranial meningiomas

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Abstract

Fractionated external beam radiotherapy (EBRT) has multiple roles in the management of intracranial meningiomas. In multiple series post-operative EBRT has shown improved progression-free survival following subtotal resection and a reduction in long-term failures following an apparent gross total resection. In the definitive setting, the use of EBRT has increased as the growing utilization of neuro-imaging for various conditions identifies skull-based lesions which are not easily resectable. Optic nerve sheath meningiomas represent a classic example of the use of definitive EBRT, given the frequent visual sequelae of surgery or observation. EBRT planning is highly individualized and requires a detailed understanding of tumor grade, adjacent radiosensitive structures such as the anterior optic apparatus, and radiographic characteristics of the tumor such as hyperostosis.

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COI Disclosure: Minesh Mehta has or has had the following roles in the last 2 years (2009-2010); Consultant: Adnexus, Bayer, Merck, Roche, Tomotherapy; Stock Options: Colby, Pharmacyclics, Procertus, Stemina Tomotherapy; Data Safety Monitoring Boards: Apogenix ;Board of Directors: Pharmacyclics; Medical Advisory Boards: Colby, Stemina, Procertus; Speaker: Merck.

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  1. Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, 600 Highland Avenue, Madison, WI, 53792, USA

    Vinai Gondi, Wolfgang A. Tome & Minesh P. Mehta

  2. Department of Medical Physics, University of Wisconsin Comprehensive Cancer Center, Madison, WI, USA

    Wolfgang A. Tome

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Gondi, V., Tome, W.A. & Mehta, M.P. Fractionated radiotherapy for intracranial meningiomas. J Neurooncol 99, 349–356 (2010). https://doi.org/10.1007/s11060-010-0368-5

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