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Emerging functions of microRNAs in glioblastoma

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Abstract

Distinct patterns of microRNA expression have been observed in glioblastomas. The functional significance of some of these microRNAs is beginning to emerge. This data indicates that microRNAs play roles in multiple hallmark biological characteristics of glioblastoma, including cell proliferation, invasion, glioma stem cell behavior, and angiogenesis. Research in this area is quickly gathering pace and is illuminating important aspects of the disease that may ultimately lead to novel therapeutic interventions, as well as diagnostic and prognostic tools for brain tumors.

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Acknowledgements

The authors would like to acknowledge the National Institutes of Health, the Esther L. Dardinger Endowment for Neuro-oncology and Neurosciences and The Thomas Jeffrey Hayden Foundation for their support.

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  1. Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, OH, 43210, USA

    Sean Lawler & E. Antonio Chiocca

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Correspondence to Sean Lawler.

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Lawler, S., Chiocca, E.A. Emerging functions of microRNAs in glioblastoma. J Neurooncol 92, 297–306 (2009). https://doi.org/10.1007/s11060-009-9843-2

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