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Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases

  • Clinical study - patient study
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Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Background The efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in combination with whole brain radiotherapy (WBRT), for the treatment of 1–4 brain metastases, using a non invasive fixation of the skull, was investigated. Methods Between 04/2001 and 01/2006 30 patients with 44 brain metastases underwent irradiation. Every patient received WBRT (10 × 3 Gy); 41/44 lesions received HSRT boost with a median dose fraction of 6 Gy, the fractionation schemes were 3 × 6 Gy and 4 × 8 Gy; a median total dose of 18 Gy was delivered to the tumor isocenter. Results The median survival period was 9.15 months, the actuarial 1-year overall survival and freedom from new brain metastases were 36.6% and 87.9%, respectively; at univariate analysis Karnofsky Performance Status (KPS) was statistically significant (P = 0.05); the actuarial 1-year local control for the 41/44 lesions was 86.1%. No patient had acute or late complications. Conclusions HSRT as a concomitant boost during WBRT is a safe and well tolerated treatment for selected patients with brain metastases.

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Abbreviations

HSRT:

Hypofractionated stereotactic radiotherapy

SRS:

Stereotactic radio-surgery

WBRT:

Whole brain radiotherapy

KPS:

Karnofsky performance status

BED:

Biologic effective dose

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Authors and Affiliations

  1. Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata University General Hospital, V.le Oxford 81, 00133, Rome, Italy

    Cesare Giubilei, Gianluca Ingrosso, Marco D’Andrea, Michaela Benassi & Riccardo Santoni

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  1. Cesare Giubilei
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  2. Gianluca Ingrosso
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  3. Marco D’Andrea
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  4. Michaela Benassi
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  5. Riccardo Santoni
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Correspondence to Gianluca Ingrosso.

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Giubilei, C., Ingrosso, G., D’Andrea, M. et al. Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases. J Neurooncol 91, 207–212 (2009). https://doi.org/10.1007/s11060-008-9700-8

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  • DOI: https://doi.org/10.1007/s11060-008-9700-8

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