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FDG-PET to predict different patterns of progression in multicentric glioblastoma: a case report

  • Clinical-Patient Studies
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Abstract

True multicentric glioblastoma multiforme (GBM) is rare and consists of separate distinct tumors in different cerebral lobes or hemispheres without any apparent route of dissemination. Few data are available describing its imaging using positron emission tomography (PET) with [18F]-fluoro-2-deoxy-d-glucose (FDG). In this paper, we report on the case of a man with bifocal tumor in the right frontal and temporal lobes who underwent FDG-PET imaging. Visual and semiquantitative analysis showed two different metabolic patterns with much more intense uptake in the smaller temporal lesion. Subtotal surgical removal of the main frontal lesion allowed satisfactory control in the operative site, whereas the temporal lesion was rapidly progressive with occurrence of necrosis, which led to a second neurosurgery. The diagnosis of glioblastoma was confirmed by neuropathological examination in both cases but with much higher immunohistochemical expression of O6-methylguanine-DNA-methyltransferase (MGMT) in the temporal lesion. This report illustrates the potential interest of FDG-PET in multicentric GBMs to identify different metabolic patterns, in accordance with clinical, morphological, and molecular aggressiveness.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Centre Hospitalo-Universitaire de la Timone (CHU Timone), 264 Rue Saint-Pierre, 13385, Marseille Cedex 5, France

    Cécile Colavolpe, Eric Guedj & Olivier Mundler

  2. Department of Neurosurgery, CHU Timone, 264 Rue Saint-Pierre, 13385, Marseille Cedex 5, France

    Philippe Metellus

  3. Department of Neuro-oncology, CHU Timone, 264 Rue Saint-Pierre, 13385, Marseille Cedex 5, France

    Maryline Barrie & Olivier Chinot

  4. Department of Pathology, CHU Timone, 264 Rue Saint-Pierre, 13385, Marseille Cedex 5, France

    Dominique Figarella-Branger

Authors
  1. Cécile Colavolpe
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  2. Eric Guedj
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  3. Philippe Metellus
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  4. Maryline Barrie
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  5. Dominique Figarella-Branger
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  6. Olivier Mundler
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  7. Olivier Chinot
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Correspondence to Cécile Colavolpe.

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Colavolpe, C., Guedj, E., Metellus, P. et al. FDG-PET to predict different patterns of progression in multicentric glioblastoma: a case report. J Neurooncol 90, 47–51 (2008). https://doi.org/10.1007/s11060-008-9629-y

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  • DOI: https://doi.org/10.1007/s11060-008-9629-y

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