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Evaluation of fluoride-labeled boronophenylalanine-PET imaging for the study of radiation effects in patients with glioblastomas

  • Clinical-Patient Studies
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Abstract

Here we demonstrate that differentiation between glioblastoma (GB) tumor progression (TP) and radiation necrosis (RN) can be achieved with fluoride-labeled boronoalanine positron emission tomography (F-BPA-PET). F-BPA-PET images were obtained from histologically verified 38 GB, 8 complete RN, and 5 RN cases with partial residual tumors. The lesion/normal (L/N) ratios for these groups were 4.2 ± 1.4, 1.5 ± 0.3, and 2.0 ± 0.3, respectively. Ten GB patients underwent F-BPA-PET twice (once before and once after radiation treatment) due to enlargement of the original lesion or the development of new lesions post radiation. The L/N ratios of ten original site lesions had decreased by the second PET, and these lesions were revealed to be RN. In contrast, the L/N ratios of two lesions distant from the original site increased, and these lesions were revealed as cases of TP. Repeat PET imaging was found to be useful for evaluating changes in GB-associated tumor activity with respect to the treatment received.

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Acknowledgments

This work was partly supported by a Grant-in-Aid for Scientific Research (B) (16390422, 19390385) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology to Shin-Ichi Miyatake. This work was also supported in part by the Takeda Science Foundation for Osaka Medical College. We are also grateful to Mr. Horii at Nishijin Hospital for technical support with the PET study.

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Authors and Affiliations

  1. Department of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan

    Minoru Miyashita, Shin-Ichi Miyatake, Kunio Yokoyama, Shinji Kawabata, Yoshinaga Kajimoto & Toshihiko Kuroiwa

  2. Department of Anatomy & Cell Biology, Osaka Medical College, Takatsuki, Osaka, Japan

    Masa-Aki Shibata & Yoshinori Otsuki

  3. Cancer Intelligence Care System, Inc., Tokyo, Japan

    Yoshio Imahori

  4. Department of Agriculture, Osaka Prefectural University, Sakai, Osaka, Japan

    Mitsunori Kirihata

  5. Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Kumatori, Osaka, Japan

    Koji Ono

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  1. Minoru Miyashita
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  2. Shin-Ichi Miyatake
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Correspondence to Shin-Ichi Miyatake.

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Miyashita, M., Miyatake, SI., Imahori, Y. et al. Evaluation of fluoride-labeled boronophenylalanine-PET imaging for the study of radiation effects in patients with glioblastomas. J Neurooncol 89, 239–246 (2008). https://doi.org/10.1007/s11060-008-9621-6

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  • DOI: https://doi.org/10.1007/s11060-008-9621-6

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