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Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature

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Abstract

Among intracranial germinomas, basal ganglia germinomas represent a specific clinical and anatomical entity. Based on an unusual case of a basal ganglia germinoma in a 13-year-old Caucasian male, we highlight the diagnostic challenges and discuss treatment considerations in this disease.

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References

  1. Borg M (2003) Germ cell tumours of the central nervous system in children-controversies in radiotherapy. Med Pediatr Oncol 40:367–374

    Article  PubMed  Google Scholar 

  2. Packer RJ, Cohen BH, Cooney K (2000) Intracranial germ cell tumors. Oncologist 5:312–320

    PubMed  CAS  Google Scholar 

  3. Ono N, Inoue HK, Naganuma H et al (1986) Diagnosis of germinal neoplasm in the thalamus and basal ganglia. Surg Neurol 26:24–28

    Article  PubMed  CAS  Google Scholar 

  4. Yasue M, Tanaka H, Nakajima M et al (1993) Germ cell tumors of the basal ganglia and thalamus. Pediatr Neurosurg 19:121–126

    Article  PubMed  CAS  Google Scholar 

  5. Kobayashi H, Yamada H, Sakai N et al (1990) Germ cell tumor arising in the basal ganglia in a female–case report. Neurol Med Chir (Tokyo) 30:123–126

    Article  CAS  Google Scholar 

  6. Calaminus G, Alapetite C, Frappaz D et al Malignant CNS germ cell tumors (GCTS): interim analysis after 5 years of SIOP CNS GCT 96 In: 39th ASCO Annual Meeting. Chicago

  7. Oyama N, Terae S, Saitoh S et al (2005) Bilateral germinoma involving the basal ganglia and cerebral white matter. AJNR Am J Neuroradiol 26:1166–1169

    PubMed  Google Scholar 

  8. Garcia-Santos JM, Torres del Rio S, Sanchez A et al (2002) Basal ganglia and thalamic tumours: an imaging approximation. Childs Nerv Syst 18:412–425

    Article  PubMed  Google Scholar 

  9. Takeda N, Fujita K, Katayama S et al (2004) Germinoma of the basal ganglia. An 8-year asymptomatic history after detection of abnormality on CT. Pediatr Neurosurg 40:306–311

    Article  PubMed  Google Scholar 

  10. Tamaki N, Lin T, Shirataki K et al (1990) Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 6:3–7

    Article  PubMed  CAS  Google Scholar 

  11. Fujimaki T, Matsutani M, Funada N et al (1994) CT and MRI features of intracranial germ cell tumors. J Neurooncol 19:217–226

    Article  PubMed  CAS  Google Scholar 

  12. Moon WK, Chang KH, Kim IO et al (1994) Germinomas of the basal ganglia and thalamus: MR findings and a comparison between MR and CT. AJR Am J Roentgenol 162:1413–1417

    PubMed  CAS  Google Scholar 

  13. Wong LW, Jayakumar CR (1997) Germinoma of the basal ganglia and thalamus–CT and MRI findings. Singapore Med J 38:444–446

    PubMed  CAS  Google Scholar 

  14. Okamoto K, Ito J, Ishikawa K et al (2002) Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology 44:389–394

    Article  PubMed  CAS  Google Scholar 

  15. Rossi A, Garre ML, Ravegnani M et al (2006) Bilateral germinoma of the basal ganglia. Pediatr Blood Cancer. doi: 1002/pbc.20905

  16. Okamoto K, Ito J, Ishikawa K et al (2000) Diffusion-weighted echo-planar MR imaging in differential diagnosis of brain tumors and tumor-like conditions. Eur Radiol 10(8):1342–1350

    Article  PubMed  CAS  Google Scholar 

  17. Kim CH, Paek SH, Park IA et al (2002) Cerebral germinoma with hemiatrophy of the brain: report of three cases. Acta Neurochir (Wien) 144:145–150

    Article  CAS  Google Scholar 

  18. Ozelame RV, Shroff M, Wood B et al (2006) Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy. Pediatr Radiol 36:325–330

    Article  PubMed  Google Scholar 

  19. Liu E, Robertson RL, du Plessis A et al (1999) Basal ganglia germinoma with progressive cerebral hemiatrophy. Pediatr Neurol 20:312–314

    Article  PubMed  CAS  Google Scholar 

  20. Panigrahy A, Krieger M, Moore K et al (2005) Preoperative MR characterization of pineal germinomas: combined diffusion weighted, diffusion tensor and MR spectroscopic imaging. Neuro Oncol (7):521 (abstract)

  21. Rushing EJ, Sandberg GD, Judkins AR et al (2006) Germinoma: unusual imaging and pathological characteristics. Report of two cases. J Neurosurg 104:143–148

    Article  PubMed  Google Scholar 

  22. Huh SJ, Shin KH, Kim IH et al (1996) Radiotherapy of intracranial germinomas. Radiother Oncol 38:19–23

    Article  PubMed  CAS  Google Scholar 

  23. Maity A, Shu HK, Janss A et al (2004) Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years’ experience in a single center. Int J Radiat Oncol Biol Phys 58:1165–1170

    PubMed  Google Scholar 

  24. Bamberg M, Kortmann RD, Calaminus G et al (1999) Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17:2585–2592

    PubMed  CAS  Google Scholar 

  25. Shikama N, Ogawa K, Tanaka S et al (2005) Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients. Cancer 104:126–134

    Article  PubMed  Google Scholar 

  26. Haas-Kogan DA, Missett BT, Wara WM et al (2003) Radiation therapy for intracranial germ cell tumors. Int J Radiat Oncol Biol Phys 56:511–518

    Article  PubMed  Google Scholar 

  27. Ogawa K, Shikama N, Toita T et al (2004) Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients. Int J Radiat Oncol Biol Phys 58:705–713

    PubMed  Google Scholar 

  28. Rogers SJ, Mosleh-Shirazi MA, Saran FH (2005) Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol 6:509–519

    Article  PubMed  CAS  Google Scholar 

  29. Shibamoto Y, Sasai K, Oya N et al (2001) Intracranial germinoma: radiation therapy with tumor volume-based dose selection. Radiology 218:452–456

    PubMed  CAS  Google Scholar 

  30. Baranzelli MC, Patte C, Bouffet E et al (1997) Nonmetastatic intracranial germinoma: the experience of the French Society of Pediatric Oncology. Cancer 80:1792–1797

    Article  PubMed  CAS  Google Scholar 

  31. Fouladi M, Grant R, Baruchel S et al (1998) Comparison of survival outcomes in patients with intracranial germinomas treated with radiation alone versus reduced-dose radiation and chemotherapy. Childs Nerv Syst 14:596–601

    Article  PubMed  CAS  Google Scholar 

  32. Kobayashi T, Kageyama N, Kida Y et al (1981) Unilateral germinomas involving the basal ganglia and thalamus. J Neurosurg 55:55–62

    Article  PubMed  CAS  Google Scholar 

  33. Elizabeth J, Menon G, Bhattacharya RN et al (2002) Germinoma of the basal ganglia: a case report and review of literature. Neurol India 50:84–86

    PubMed  CAS  Google Scholar 

  34. Fujita T, Yamada K, Saitoh H et al (1992) Intracranial germinoma and Down’s syndrome–case report. Neurol Med Chir (Tokyo) 32:163–165

    Article  CAS  Google Scholar 

  35. Garton HJ, Walker ML, Boyer RS et al (1997) A 14-year-old male with basal ganglia tumor. Pediatr Neurosurg 26:219–224

    Article  PubMed  CAS  Google Scholar 

  36. Matsumura N, Kurimoto M, Endo S et al (1998) Intracranial germinoma associated with Down’s syndrome. Report of 2 cases. Pediatr Neurosurg 29:199–202

    Article  PubMed  CAS  Google Scholar 

  37. Tanabe M, Mizushima M, Anno Y et al (1997) Intracranial germinoma with Down’s syndrome: a case report and review of the literature. Surg Neurol 47:28–31

    Article  PubMed  CAS  Google Scholar 

  38. Zissiadis Y, Dutton S, Kieran M et al (2001) Stereotactic radiotherapy for pediatric intracranial germ cell tumors. Int J Radiat Oncol Biol Phys 51:108–112

    PubMed  CAS  Google Scholar 

  39. Huh SJ, Kim IH, Ha SW et al (1992) Radiotherapy of germinomas involving the basal ganglia and thalamus. Radiother Oncol 25:213–215

    Article  PubMed  CAS  Google Scholar 

  40. Nakasu Y, Takeichi T, Takayama S et al (1993) Poikilothermia in a female patient with a germinoma in the basal ganglia. Acta Neurochir (Wien) 120:190–192

    Article  CAS  Google Scholar 

  41. Sugimoto K, Nakahara I, Nishikawa M (2002) Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. Neurosurgery 50:613–616

    Article  PubMed  Google Scholar 

  42. Aoyama H, Shirato H, Kakuto Y et al (1998) Pathologically-proven intracranial germinoma treated with radiation therapy. Radiother Oncol 47:201–205

    Article  PubMed  CAS  Google Scholar 

  43. Klein O, Voirin J, Civit T et al (2007) Germinoma located in the basal ganglia in an 8-year-old girl. Childs Nerv Syst 23:105–108

    Article  PubMed  CAS  Google Scholar 

  44. Sartori S, Laverda AM, Calderone M et al (2007) Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst 23:1341–1345

    Article  PubMed  CAS  Google Scholar 

  45. Aoyama I, Kondo A, Ogawa H et al (1994) Germinoma in siblings: case reports. Surg Neurol 41:313–317

    Article  PubMed  CAS  Google Scholar 

  46. Chik K, Li C, Shing MM et al (1999) Intracranial germ cell tumors in children with and without Down syndrome. J Pediatr Hematol Oncol 21:149–151

    Article  PubMed  CAS  Google Scholar 

  47. Utsuki S, Oka H, Tanizaki Y et al (2006) Histological features of intracranial germinomas not disappearing immediately after radiotherapy. Neurol Med Chir (Tokyo) 46:429–433

    Article  Google Scholar 

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Correspondence to Ute Bartels.

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Villani, A., Bouffet, E., Blaser, S. et al. Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature. J Neurooncol 88, 309–314 (2008). https://doi.org/10.1007/s11060-008-9568-7

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