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Intracranial recurrence and distant metastasis of scalp dermatofibrosarcoma protuberans

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Abstract

Only few cases of scalp dermatofibrosarcoma protuberans with intracranial and distant metastasis have been reported. Here we report a case of scalp dermatofibrosarcoma protuberans with frequent local recurrence, intracranial invasion and with distant lung metastasis during 6 years of treatment. We would like to emphasize difficulties in surgical treatment of such invasive and locally recurrent tumors of scalp, and necessity to understand new molecular pathogenesis of dermatofibrosarcoma protuberans and potential treatment strategy with imatinib for patients with surgically untreatable disease. Close surveillance of patients with scalp dermatofibrosarcoma is necessary due recurrence nature of tumor.

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References

  1. Chang CK, Jacobs IA, Salti GI (2004) Outcomes of surgery for dermatofibrosarcoma protuberans. Eur J Surg Oncol 30:341–345

    Article  PubMed  CAS  Google Scholar 

  2. Gloster HM Jr (1996) Dermatofibrosarcoma protuberans. J Am Acad Dermatol 35:355–374

    Article  PubMed  Google Scholar 

  3. Fiore M, Miceli R, Mussi C et al (2005) Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate. J Clin Oncol 23:7669–7675

    Article  PubMed  Google Scholar 

  4. Gloster HM Jr, Harris KR, Roenigk RK (1996) A comparison between Mohs micrographic surgery and wide surgical excision for the treatment of dermatofibrosarcoma protuberans. J Am Acad Dermatol 35:82–87

    Article  PubMed  Google Scholar 

  5. Cakir B, Misirlioğlu A, Gideroğlu K, Aköz T (2003) Giant fibrosarcoma arising in dermatofibrosarcoma protuberans on the scalp during pregnancy. Dermatol Surg 29(3):297–299

    Article  PubMed  Google Scholar 

  6. McPeak CJ, Cruz T, Nicastri AD (1967) Dermatofibrosarcoma protuberans: an analysis of 86 cases five with metastasis. Ann Surg 166:803–816

    Article  PubMed  CAS  Google Scholar 

  7. Criscione VD, Weinstock MA (2007) Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002. J Am Acad Dermatol 56(6):968–973

    Article  PubMed  Google Scholar 

  8. Kim SD, Park JY, Choi WS, Kim SH, Lim DJ, Chung HS (2007) Intracranial recurrence of the scalp dermatofibrosarcoma. Clin Neurol Neurosurg 109(2):172–175

    Article  PubMed  Google Scholar 

  9. Parker TL, Zitelli JA (1995) Surgical margins for excision of dermatofibrosarcoma protuberans. J Am Acad Dermatol 32(2 Pt 1):233–236

    Article  PubMed  CAS  Google Scholar 

  10. Wacker J, Khan-Durani B, Hartschuh W (2004) Modified Mohs micrographic surgery in the therapy of dermatofibrosarcoma protuberans: analysis of 22 patients. Ann Surg Oncol 11:438–444

    Article  PubMed  Google Scholar 

  11. Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR (2002) Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 100:623–626

    Article  PubMed  CAS  Google Scholar 

  12. McArthur G (2004) Molecularly targeted treatment for dermatofibrosarcoma protuberans. Semin Oncol 31(2 Suppl 6):30–36

    Article  PubMed  CAS  Google Scholar 

  13. Rubin BP, Schuetze SM, Eary JF et al (2002) Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 20:3586–3591

    Article  PubMed  CAS  Google Scholar 

  14. Labropoulos SV, Fletcher JA, Oliveira AM, Papadopoulos S, Razis ED (2005) Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate. Anticancer Drugs 16:461–466

    Article  PubMed  CAS  Google Scholar 

  15. Taylor HB, Helwig EB (1962) Dermatofibrosarcoma protuberans. A study of 115 cases. Cancer 15: 717–725

    Article  PubMed  CAS  Google Scholar 

  16. Loss L, Zeitouni NC (2005) Management of scalp dermatofibrosarcoma protuberans. Dermatol Surg 31(11 Pt 1):1428–1433

    Article  PubMed  CAS  Google Scholar 

  17. Ballo MT, Zagars GK, Pisters P, Pollack A (1998) The role of radiation therapy in the management of dermatofibrosarcoma protuberans. Int J Radiat Oncol Biol Phys 40:823–827

    Article  PubMed  CAS  Google Scholar 

  18. Bowne WB, Antonescu CR, Leung DH et al (2000) Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution. Cancer 88:2711–2720

    Article  PubMed  CAS  Google Scholar 

  19. Nakra T, Cook T, Douglas RS, Goldberg RA (2004) Dermatofibrosarcoma protuberans metastatic to the orbit. Arch Ophthalmol 122:1240–1241

    Article  PubMed  Google Scholar 

  20. McArthur G (2007) Dermatofibrosarcoma protuberans: recent clinical progress. Ann Surg Oncol 14(10):2876–2886

    Article  PubMed  Google Scholar 

  21. Sjoblom T, Shimizu A, O’Brien KP et al (2001) Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Cancer Res 61:5778–5783

    PubMed  CAS  Google Scholar 

  22. Greco A, Roccato E, Miranda C, Cleris L, Formelli F, Pierotti MA (2001) Growth-inhibitory effect of STI571 on cells transformed by the COL1A1/PDGFB rearrangement. Int J Cancer 92:354–360

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, University hospital “Dubrava”, Av. G. Suska 6, 10 000, Zagreb, Croatia

    Jurica Marakovic, Milorad Vilendecic, Tonko Marinovic & Gordan Grahovac

  2. Department of Pathology, University hospital “Dubrava”, Zagreb, Croatia

    Smiljka Lambasa

Authors
  1. Jurica Marakovic
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  2. Milorad Vilendecic
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  3. Tonko Marinovic
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  4. Smiljka Lambasa
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  5. Gordan Grahovac
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Corresponding author

Correspondence to Gordan Grahovac.

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Marakovic, J., Vilendecic, M., Marinovic, T. et al. Intracranial recurrence and distant metastasis of scalp dermatofibrosarcoma protuberans. J Neurooncol 88, 305–308 (2008). https://doi.org/10.1007/s11060-008-9567-8

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  • DOI: https://doi.org/10.1007/s11060-008-9567-8

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