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ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin

  • Lab. Investigation-Human/Animal Tissue
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Abstract

Retinoic acid (RA) is a major chemopreventive agent which exerts strong anti-tumor activity partly by trans-repressing the Wnt/β-catenin signaling pathway in some tumor cell lines. However, the definite mechanism of RA trans-repression of the Wnt/β-catenin signaling pathway has not been elucidated clearly. In this work, we found that all-trans retinoic acid (ATRA) significantly inhibited proliferation of glioma cells, accompanied by up-regulation of expression of Axin and altered subcellular distribution of β-catenin. Transfecting C6 cells with rAxin further confirmed that increased expression of Axin is obligate for inhibition of proliferation and the increase of the cytoplasmic β-catenin. Our results suggested that Axin might play an important role in RA-mediated anti-proliferative effects of glioma cell lines.

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Acknowledgments

This work was supported by the State Key Laboratory of Cancer Biology grant, China (CBSKL 2005004). We thank Dr Zhizhong Wang at the Department of Epidemiology of the Fourth Military Medical University for assistance with Statistical analysis.

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Authors and Affiliations

  1. Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, 710032, P.R. China

    Jianrong Lu, Feng Zhang, Daqing Zhao, Liu Hong, Jie Min, Liying Zhang, Fanfan Li, Yan Yan, Hang Li, Yu Ma & Qing Li

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  1. Jianrong Lu
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  2. Feng Zhang
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  3. Daqing Zhao
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  6. Liying Zhang
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  7. Fanfan Li
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  8. Yan Yan
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  9. Hang Li
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  10. Yu Ma
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  11. Qing Li
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Correspondence to Qing Li.

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Lu, J., Zhang, F., Zhao, D. et al. ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin. J Neurooncol 87, 271–277 (2008). https://doi.org/10.1007/s11060-008-9518-4

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  • DOI: https://doi.org/10.1007/s11060-008-9518-4

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