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Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report

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Abstract

We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation. This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition. Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.

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References

  1. Shinoda J, Sakai N, Yano H, Hattori T, Ohkuma A, Sakaguchi H (2004) Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG. J Neuro-Oncol 66:25–240

    Article  Google Scholar 

  2. Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T (1997) Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 86:446–455

    Article  PubMed  CAS  Google Scholar 

  3. Askanazy M (1906) Das Teratom und Chorioepitheliom der Zwirbel. Verh Dtsch Ges Pathol 10:58–76

    Google Scholar 

  4. The Committee of the Brain Tumor Registry of Japan (2000) Report of the brain tumor registry of Japan (1969–1993) 10th edn. Neurol Med Chir 40(suppl):9–10

  5. Jennings MT, Gelman R, Hochberg F (1985) Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg 63:155–167

    PubMed  CAS  Google Scholar 

  6. Allen JC, Nisselbaum J, Epstein F, Rosen G, Schwartz MK (1979) Alphafetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid. An aid to the diagnosis and management of intracranial germ-cell tumors. J Neurosurg 51:368–374

    PubMed  CAS  Google Scholar 

  7. Chan HSL, Humphreys RP, Hendrick EB, Chuang SH, Fitz CR, Becker LE (1984) Primary intracranial choriocarcinoma: a report of two cases and a review of the literature. Neurosurgery 15:540–545

    Article  PubMed  CAS  Google Scholar 

  8. Fujii T, Itakura T, Hayashi S, Komai N, Nakamine H, Saito K (1981) Primary pineal choriocarcinoma with hemorrhage monitored by computerized tomography. J Neurosurg 55:484–487

    PubMed  CAS  Google Scholar 

  9. Kawakami Y, Yamada O, Tabuchi K, Ohmoto T, Nishimoto A (1980) Primary intracranial choriocarcinoma. J Neurosurg 53:369–374

    PubMed  CAS  Google Scholar 

  10. Sakurada K, Kayama T, Kawakami K, Saino M, Sato S (2000) A successfully operated case of choriocarcinoma with recurrent intratumoral hemorrhage. No Shinkei Geka 28:67–72

    PubMed  CAS  Google Scholar 

  11. Sato N, Sato H, Nakagawa Y, Kataoka K, Hojo H, Tamaki N, Matsumoto S (1983) Primary intracranial choriocarcinoma causing hemorrhage. Case Report. Neurol Med Chir 23:896–901

    Article  CAS  Google Scholar 

  12. Weir B, MacDonald N, Mielke B (1978) Intracranial vascular complications of choriocarcinoma. Neurosurgery 2:138–142

    Article  PubMed  CAS  Google Scholar 

  13. Nam DH, Cho BK, Shin HJ, Ahn HS, Kim IH, Wang KC (1999) Treatment of intracranial nongerminomatous malignant germ cell tumor in children: the role of each treatment modality. Childs Nerv Syst 15:185–191

    Article  PubMed  CAS  Google Scholar 

  14. Wass JAH, Jones AE, Ress LH, Besser GM (1982) hCGβ-producing pineal choriocarcinoma. Clin Endocrinol 17:423–431

    CAS  Google Scholar 

  15. Matsutani M, Ushio Y, Abe H, Yamashita J, Shibui S, Fujimaki T, Takakura K, Nomura K, Tanaka R, Fukui M, Yoshimoto T, Hayakawa T, Nagashima T, Kurisu K, Kayama T, Japanese Pediatric Brain Tumor Study Group (1998): Combined chemotherapy and radiation therapy for central nervous system germ cell tumors: preliminary results of a phase II study of the Japanese Pediatric Brain Tumor Study Group. Neurosurg Focus 5: Article 7

  16. Kochi M, Itoyama Y, Shiraishi S, Kitamura I, Marubayashi T, Ushio Y (2003) Successful treatment of intracranial nongerminomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumors. J Neurosurg 99:106–114

    PubMed  Google Scholar 

  17. Ushio Y, Kochi M, Kuratsu J, Itoyama Y, Marubayashi T (1999) Preliminary observations for a new treatment in children with primary intracranial yolk sac tumor or embryonal carcinoma. Report of five cases. J Neurosurg 90:133–134

    Article  PubMed  CAS  Google Scholar 

  18. Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ (1994) Treatment of nongerminomatous germ-cell tumors of the pineal region. Neurosurgery 34:524–529

    Article  PubMed  CAS  Google Scholar 

  19. Horowitz NM, Rowlings PA (1997) An update from the international bone marrow transplant registry and the autologous blood and marrow transplant registry on current activity in hematopoietic stem cell transplantation. Curr Opin Hematol 4:395–400

    Article  PubMed  CAS  Google Scholar 

  20. Santini G, Salvagno L, Leoni P, Chisesi T, De Souza C, Sertoli MR, Rubagotti A, Congiu AM, Centurioni R, Olivieri A, Tedeschi L, Vespignani M, Nati S, Soracco M, Porcellini A, Contu A, Guarnaccia C, Pescosta N, Majolino I, Spriano M, Vimercati R, Rossi E, Zambaldi G, Mangoni L, Rizzoli V (1998) VACOP-B versus VACOP-B plus autologous bone marrow transplantation for advanced diffuse non-Hodgkin’s lymphoma: results of a prospective randomized trial by the Non-Hodgkin Lymphoma Cooperative Study Group. J Clin Oncol 16:2796–2802

    PubMed  CAS  Google Scholar 

  21. Droz JP, Pico JL, Kramar A (1993) Role of autologous bone marrow transplantation in germ-cell cancer. Urol Clin North Am 20:161–171

    PubMed  CAS  Google Scholar 

  22. Kimura H, Miyashita Y, Inoue K, Ogawa H, Kasayama M, Koga M, Sato B, Kishimito C, Nakahara K, Arita N (1995) A case report of successfully treated HCG-secreting primary intracranial choriocarcinoma by high-dose chemotherapy with autologous marrow transplantation. Nippon Naika Gakkai Zasshi 84:132–134

    PubMed  CAS  Google Scholar 

  23. Tada T, Takizawa T, Nakazato F, Kobayashi S, Koike K, Oguchi M, Ishii E, Amano Y (1999) Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue. J Neuro-Oncol 44:71–76

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery and Pediatrics, School of Medicine, The University of Tokushima, Kuramoto-cho 3-18-15, 770, Tokushima, Japan

    Teruyoshi Kageji, Shinji Nagahiro, Kazuhito Matsuzaki, Yasuhiko Kanematsu, Minoru Nakatani, Yasuhiko Okamoto & Tsutomu Watanabe

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  1. Teruyoshi Kageji
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  2. Shinji Nagahiro
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  3. Kazuhito Matsuzaki
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  4. Yasuhiko Kanematsu
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  5. Minoru Nakatani
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  6. Yasuhiko Okamoto
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  7. Tsutomu Watanabe
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Correspondence to Teruyoshi Kageji.

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Kageji, T., Nagahiro, S., Matsuzaki, K. et al. Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report. J Neurooncol 83, 199–204 (2007). https://doi.org/10.1007/s11060-006-9311-1

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  • DOI: https://doi.org/10.1007/s11060-006-9311-1

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