Abstract
The SOX group E transcription factors play an integral role in the specification and differentiation of astrocytes and oligodendrocytes. We have examined the pattern of expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry. Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is characterized by an increase of SOX9 only.
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Acknowledgement
Antibodies against SOX9 and SOX10 were kindly provided by Prof. Wegner, Erlangen. This work was supported by the Fördergemeinschaft Kinder-Krebs-Zentrum Hamburg e.V.
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Note added in proof Bannykh et al. [18] also describe expression of SOX10 in human gliomas