Summary
Dysembryoplastic neuroepithelial tumors (DNET) are usually benign lesions that arise in cortical regions and are discovered after new onset of seizure. These lesions have many different imaging characteristics. We report a patient with a presumed low-grade medial temporal lobe lesion that was followed for many years without any change in size or imaging characteristics. This previously non-enhancing tumor evolved to become contrast enhanced on routine imaging without apparent tumor growth. The patient underwent surgery, and the pathology was confirmed as a DNET with no atypical changes. This case demonstrates the potential that DNETs may exhibit a changing MRI pattern over time. Natural history, imaging characteristics, and management are reviewed.
Similar content being viewed by others
References
Kleihues P, Cavenee WK, (eds): World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Nervous System Lyon IARC Press 2000
Daumas-Duport C, Dysembryoplastic neuroepithelial tumours Brain Pathol 3:283–295, 1993
Shin JH, Lee HK, Khang SK, Kim DW, Jeong AK, Ahn KJ, Choi CG, Suh DC, Neuronal tumors of the central nervous system: radiologic findings and pathologic correlation Radiographics 22:1177–1189, 2002
Fernandez C, Girard N, Paz Paredes A, Bouvier-Labit C, Lena G, Figarella-Branger D, The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases AJNR Am J Neuroradiol 24:829–834, 2003
Bulakbasi N, Kocaoglu M, Ors F, Tayfun C, Ucoz T, Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors AJNR Am J Neuroradiol 24:225–233, 2003
Maehara T, Nariai T, Arai N, Kawai K, Shimizu H, Ishii K, Ishiwata K, Ohno K, Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy Epilepsia 45:41–45, 2004
Ostertun B, Wolf HK, Campos MG, Matus C, Solymosi L, Elger CE, Schramm J, Schild HH, Dysembryoplastic neuroepithelial tumors: MR and CT evaluation AJNR Am J Neuroradiol 17:419–430, 1996
Acknowledgment
We thank Kristin Kraus for her editorial assistance in preparing this paper.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jensen, R.L., Caamano, E., Jensen, E.M. et al. Development of contrast enhancement after long-term observation of a dysembryoplastic neuroepithelial tumor. J Neurooncol 78, 59–62 (2006). https://doi.org/10.1007/s11060-005-9054-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11060-005-9054-4