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Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas

  • Clinical--patient studies
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Background

The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated.

Methods

p16 Expression was examined in 20 anaplastic astrocytoma and 42 glioblastoma patients by immunohistochemical analysis, and the relationship between both cytoplasmic and nuclear p16 expression and prognosis analyzed.

Results

The cytoplasmic expression of p16 statistically correlated with poor prognosis. On the other hand, no correlation was observed between p16 nuclear expression and patient survival.

Conclusion

The cytoplasmic immunoreactivity of p16 appears to be an unfavorable prognostic indicator in high-grade astrocytoma patients. The localization of p16 expression should be determined when evaluating the prognosis of these patients.

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Acknowledgement

This study was supported in part by grants-in-aid from the Ministry of Education, Science and Culture, Japan.

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Authors and Affiliations

  1. Department of Neurosurgery, Hiroshima University, Kasumi 1-2-3, Minami-Ku, 734-8551, Hiroshima-Shi, Japan

    Muhamad Thohar Arifin, Seiji Hama, Yoshinori Kajiwara, Kazuhiko Sugiyama, Taiichi Saito, Fumiyuki Yamasaki, Kazunori Arita & Kaoru Kurisu

  2. Department of Radiation Biology, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

    Shinya Matsuura

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  1. Muhamad Thohar Arifin
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  2. Seiji Hama
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  3. Yoshinori Kajiwara
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  9. Kaoru Kurisu
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Correspondence to Muhamad Thohar Arifin.

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Arifin, M.T., Hama, S., Kajiwara, Y. et al. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. J Neurooncol 77, 273–277 (2006). https://doi.org/10.1007/s11060-005-9037-5

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  • DOI: https://doi.org/10.1007/s11060-005-9037-5

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