Summary
The diagnosis of Gliomatosis cerebri (GC) is known to be difficult and is still a matter of debate. We describe an in␣vivo case of GC associated with a pituitary tumor. A 47-year-old woman presented with short-term memory loss. A MRI revealed the presence of a pituitary enhancing tumor and a diffuse lesion involving the brain. A left pterional craniotomy with partial temporal lobectomy and removal of the pituitary lesion were performed in order to obtain diagnosis. The histological analyses showed a pituitary non-functioning tumor and a GC consisting of neoplastic oligodendrocytes and astrocytes. Both lesions showed nuclear immunoreactivity for progesterone receptors (PGr) and estrogen receptors (EGr). This result could suggest there is a common receptor substrate in these tumors. In this case hormones could constitute a common step in tumorigenesis of both lesions.
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Mangiola, A., Bonis, P.D., Guerriero, M. et al. Gliomatosis Cerebri and Pituitary Adenoma: Case Report and Literature Review. J Neurooncol 74, 321–324 (2005). https://doi.org/10.1007/s11060-004-7901-3
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DOI: https://doi.org/10.1007/s11060-004-7901-3