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Multi-Focal Gliosarcoma: A Case Report and Review of the Literature

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Summary

Gliosarcoma (GS) is an uncommon malignant brain tumor with biphasic tissue pattern consisted of both glial and sarcomatous components. It usually occurs in adult population of middle age. We report a rare case of multi-focal GS that was initially interpreted as metastases of extra-cranial tumor. The histological examination revealed the biphasic pattern of a GS. The patient was treated with postoperative external radiation therapy and had poor prognosis. To our knowledge this is the second published case of GS with multi-focal presentation. In this study we also review the literature on clinicopathological aspects of GS.

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References

  1. H. Stroebe (1895) ArticleTitleUeber Entstehung und Bau der Gehirngliome Bietr Pathol Anat Allg Pathol 18 405–486

    Google Scholar 

  2. P Kleihues PC Burger BW. Scheithauer (1993) ArticleTitleThe new WHO classification of brain tumours Brain Pathol 3 255–268 Occurrence Handle8293185

    PubMed  Google Scholar 

  3. E Galanis JC Buckner RP Dinapoli BW Scheithauer RB Jenkins CH Wang JR O’Fallon G Farr SuffixJr. (1998) ArticleTitleClinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results J Neurosurg 89 425–430 Occurrence Handle9724117

    PubMed  Google Scholar 

  4. F Maiuri L Stella D Benvenuti A Giamundo G. Pettinato (1990) ArticleTitleCerebral gliosarcomas: correlation of computed tomographic findings, surgical aspect, pathological features, and prognosis Neurosurgery 26 261–267 Occurrence Handle10.1097/00006123-199002000-00013 Occurrence Handle2308674

    Article  PubMed  Google Scholar 

  5. JM Meis KL Ho JS. Nelson (1990) ArticleTitleGliosarcoma: a histologic and immunohistochemical reaffirmation Mod Pathol 3 19–24 Occurrence Handle2155418

    PubMed  Google Scholar 

  6. RA Morantz I Feigin 3rd. Ransohoff J (1976) ArticleTitleClinical and pathological study of 24 cases of gliosarcoma J Neurosurg 45 398–408 Occurrence Handle956876

    PubMed  Google Scholar 

  7. N Okami T Kawamata O Kubo F Yamane H Kawamura T. Hori (2002) ArticleTitleInfantile gliosarcoma: a case and a review of the literature Childs Nerv Syst 18 351–355 Occurrence Handle10.1007/s00381-002-0602-3 Occurrence Handle12172946

    Article  PubMed  Google Scholar 

  8. J Lutterbach R Guttenberger A. Pagenstecher (2001) ArticleTitleGliosarcoma: a clinical study Radiother Oncol 61 57–64 Occurrence Handle10.1016/S0167-8140(01)00415-7 Occurrence Handle11578729

    Article  PubMed  Google Scholar 

  9. JM Meis KL Martz JS. Nelson (1991) ArticleTitleMixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases Cancer 67 2342–2349 Occurrence Handle1849447

    PubMed  Google Scholar 

  10. RL Woltjer RJ Weil PL Moots MD. Johnson (2003) ArticleTitlePathologic quiz case: cerebellar hemorrhage in an octogenarian. Gliosarcoma Arch Pathol Lab Med 127 345–346 Occurrence Handle12653581

    PubMed  Google Scholar 

  11. JA Ozolek SD Finkelstein ME. Couce (2004) ArticleTitleGliosarcoma with epithelial differentiation: immunohistochemical and molecular characterization. A case report and review of the literature Mod Pathol 17 739–745 Occurrence Handle10.1038/modpathol.3800109 Occurrence Handle15148503

    Article  PubMed  Google Scholar 

  12. I Feigin LB Allen L Lipkin SW. Gross (1958) ArticleTitleThe endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation Cancer 11 264–277 Occurrence Handle13511345

    PubMed  Google Scholar 

  13. RD McComb TR Jones SV Pizzo DD. Bigner (1982) ArticleTitleImmunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma J Neuropathol Exp Neurol 41 479–489 Occurrence Handle6286891

    PubMed  Google Scholar 

  14. N Kochi H. Budka (1987) ArticleTitleContribution of histiocytic cells to sarcomatous development of the gliosarcoma An immunohistochemical study. Acta Neuropathol (Berl) 73 124–130 Occurrence Handle10.1007/BF00693777

    Article  Google Scholar 

  15. JR Perry LC Ang JM Bilbao PJ. Muller (1995) ArticleTitleClinicopathologic features of primary and postirradiation cerebral gliosarcoma Cancer 75 2910–2918 Occurrence Handle7773942

    PubMed  Google Scholar 

  16. RM Reis D Konu-Lebleblicioglu JM Lopes P Kleihues H. Ohgaki (2000) ArticleTitleGenetic profile of gliosarcomas Am J Pathol 156 425–432 Occurrence Handle10666371

    PubMed  Google Scholar 

  17. W Biernat A Aguzzi U Sure JW Grant P Kleihues ME. Hegi (1995) ArticleTitleIdentical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells J Neuropathol Exp Neurol 54 651–656 Occurrence Handle7666053

    PubMed  Google Scholar 

  18. RH Boerman K Anderl J Herath T Borell N Johnson J Schaeffer-Klein A Kirchhof AK Raap BW Scheithauer RB. Jenkins (1996) ArticleTitleThe glial and mesenchymal elements of gliosarcomas share similar genetic alterations J Neuropathol Exp Neurol 55 973–981 Occurrence Handle8800093

    PubMed  Google Scholar 

  19. KA Lieberman CE Fuller RD Caruso RL. Schelper (2001) ArticleTitlePostradiation gliosarcoma with osteosarcomatous components Neuroradiology 43 555–558 Occurrence Handle10.1007/s002340000531 Occurrence Handle11512585

    Article  PubMed  Google Scholar 

  20. B Kaschten P Flandroy M Reznik H Hainaut A. Stevenaert (1995) ArticleTitleRadiation-induced gliosarcoma. Case report and review of the literature J Neurosurg 83 154–162 Occurrence Handle7782835

    PubMed  Google Scholar 

  21. RE Coleman JM Hoffman MW Hanson HD Sostman SC. Schold (1991) ArticleTitleClinical application of PET for the evaluation of brain tumors J Nucl Med 32 616–622 Occurrence Handle2013802

    PubMed  Google Scholar 

  22. A Niranjan LD Lunsford GT Gobbel D Kondziolka A Maitz JC. Flickinger (2000) ArticleTitleBrain tumor radiosurgery: current status and strategies to enhance the effect of radiosurgery Brain Tumor Pathol 17 89–96 Occurrence Handle11210177

    PubMed  Google Scholar 

  23. MD Prados PH Gutin TL Phillips WM Wara PK Sneed DA Larson SA Lamb B Ham MK Malec CB. Wilson (1992) ArticleTitleInterstitial brachytherapy for newly diagnosed patients with malignant gliomas: the UCSF experience Int J Radiat Oncol Biol Phys 24 593–597 Occurrence Handle1429080

    PubMed  Google Scholar 

  24. HM Smilowitz JA Coderre MM Nawrocky W Tu A Pinkerton GH Jahng N Gebbers DN. Slatkin (2002) ArticleTitleThe combination of X-ray-mediated radiosurgery and gene-mediated immunoprophylaxis for advanced intracerebral gliosarcomas in rats J Neurooncol 57 9–18 Occurrence Handle10.1023/A:1015709406449 Occurrence Handle12125969

    Article  PubMed  Google Scholar 

  25. DR Sorensen M Leirdal PO Iversen M. Sioud (2002) ArticleTitleCombination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma Neoplasia 4 474–479 Occurrence Handle10.1038/sj.neo.7900271 Occurrence Handle12407440

    Article  PubMed  Google Scholar 

  26. PB Storm JL Moriarity B Tyler PC Burger H Brem J. Weingart (2002) ArticleTitlePolymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy J Neurooncol Feb; 56 IssueID3 209–217

    Google Scholar 

  27. PA Winkler A Buttner A Tomezzoli S. Weis (2000) ArticleTitleHistologically repeatedly confirmed gliosarcoma with long survival: review of the literature and report of a case Acta Neurochir (Wien) 142 91–95 Occurrence Handle10.1007/s007010050012

    Article  Google Scholar 

  28. D Weaver S Vandenberg TS Park JA. Jane (1984) ArticleTitleSelective peripancreatic sarcoma metastases from primary gliosarcoma Case report. J Neurosurg 61 599–601

    Google Scholar 

  29. DR Smith JM Hardman KM. Earle (1969) ArticleTitleContiguous glioblastoma multiforme and fibrosarcoma with extracranial metastasis Cancer 24 270–276 Occurrence Handle4307749

    PubMed  Google Scholar 

  30. BP Witwer MS Salamat DK. Resnick (2000) ArticleTitleGliosarcoma metastatic to the cervical spinal cord: case report and review of the literature Surg Neurol 54 373–378 Occurrence Handle10.1016/S0090-3019(00)00315-3 Occurrence Handle11165614

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Therapy, Neohoropoulo, P.O.B: 243, Ioannina, 45500, Greece

    E. E. Pakos, V. P. Zina, E. J. Pitouli & P. G. Tsekeris

  2. Department of Pathology, School of Medicine, University Hospital of Ioannina, University of Ioannina, Ioannina, Greece

    A. C. Goussia

Authors
  1. E. E. Pakos
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  2. A. C. Goussia
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  3. V. P. Zina
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  4. E. J. Pitouli
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  5. P. G. Tsekeris
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Correspondence to E. E. Pakos.

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Pakos, E.E., Goussia, A.C., Zina, V.P. et al. Multi-Focal Gliosarcoma: A Case Report and Review of the Literature. J Neurooncol 74, 301–304 (2005). https://doi.org/10.1007/s11060-004-7558-y

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