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Malignant Transformation of Intra-Cranial Epithelial Cysts: Systematic Article Review

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Summary

Introduction: Epidermoid and dermoid cysts are among the most benign intra cranial tumors. Their malignant transformation into squamous cell carcinoma is rare. The authors reviewed the literature.

Materials and Methods: MEDLINE and SCIENCE DIRECT searches, and examination of the references in the selected articles yielded 74 patients, 52 of whom fulfilled Garcia’s criteria and were selected for the study. Survival analyses were performed to determine whether survival differences were of statistical significance, and P < 0.05 was considered as significant.

Results: Malignant transformation is characterized by a rapid onset of symptoms, recurrence, leptomeningeal carcinomatosis (LC), and tumor enhancement at Computed Tomography Scan or Magnetic Resonance Imaging (87.8 showed this radiological feature). In this review, the SCCs were classified in five groups– (1) Initial malignant transformation of a benign cyst; (2) malignant transformation from a remnant cyst; (3) malignant transformation of a dermoid and epithelial cyst; (4) malignant transformation with leptomeningeal carcinomatosis; (5) other malignancies arising from benign cysts. The median survival was 9 months. Statistics show that LC was of poor prognosis and radiotherapy, although not statistically significant, seems effective against such lesions, with a median survival of 26 months as opposed to 3 months (P=0.077).

Conclusion: Although rare, malignant transformation of intracranial epithelial cysts has a poor prognosis and surgery followed by radiotherapy seems to be the best therapeutic modality.

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References

  1. B Guidetti FM Gagliardi (1977) ArticleTitleEpidermoid and dermoid cysts Clinical evaluation and late surgical results. J Neurosurg 47 12–18

    Google Scholar 

  2. AC Garcia PA McGarry F Rodriguez (1981) ArticleTitlePrimary intracranial squamous cell carcinoma of the right cerebellopontine angle J Neurosurg 54 824–828 Occurrence Handle7017078

    PubMed  Google Scholar 

  3. AJ Lewis PW Cooper EE Kassel ML Schwartz (1983) ArticleTitleSquamous cell carcinoma arising in a suprasellar epidermoid cyst Case report. J Neurosurg 59 538–541

    Google Scholar 

  4. B Sawan A Vital H Loiseau V Dousset D Strub C Vital (2000) ArticleTitleSquamous cell carcinoma developing in an intracranial prepontine epidermoid cyst Ann Pathol 20 253–260 Occurrence Handle10891725

    PubMed  Google Scholar 

  5. P Ernst-Heidelberg (1912) ArticleTitleHäufung dysontogenetischer Bildungen am Zentralnervensystem Verh Dtsch Pathol Ges 15 226–230

    Google Scholar 

  6. HG Henkel (1951) ArticleTitleBesondere Formen bösartiger Erkrankungen der weichen Hirnhäute Verh Dtsch Ges Pathol 35 185–188

    Google Scholar 

  7. SW Wong TB Ducker JM Powers (1976) ArticleTitleFulminating parapontine epidermoid carcinoma in a four-year-old boy Cancer 37 1525–1531 Occurrence Handle1260671

    PubMed  Google Scholar 

  8. EA Khan (1966) Metastatic tumors of the brain EC KhanEA Crosby RC Schneider (Eds) et al. Correlative Neurosurgery, Charles C Thomas. EditionNumber2 Springfield IL 225–226

    Google Scholar 

  9. RC Abramson RB Morawetz M Schlitt (1989) ArticleTitleMultiple complications from an intracranial epidermoid cyst: case report and literature review Neurosurgery 24 574–578 Occurrence Handle2651960

    PubMed  Google Scholar 

  10. Stromeyer

  11. SI Davidson JM Small (1960) ArticleTitleMalignant change in an intracranial epidermoid J Neurol Neurosurg Psychiatry 23 176–178 Occurrence Handle13814361

    PubMed  Google Scholar 

  12. H Fox EA South (1965) ArticleTitleSquamous cell carcinoma developing in an intracranial epidermoid cyst (cholesteatoma) J Neurol Neurosurg Psychiatry 28 276–281 Occurrence Handle14345685

    PubMed  Google Scholar 

  13. A Gluszcz (1962) ArticleTitleA cancer arising in a dermoid of the brain. A case report. J Neuropathol Exp Neurol 21 385–387

    Google Scholar 

  14. D Ebisubani F Hamazaki H Oka J Okada T Ohshima K Matsumoto K Izumi (1990) ArticleTitleAn autopsy case of primary intracranial squamous cell carcinoma No Shinkei Geka 18 193–198 Occurrence Handle2186294

    PubMed  Google Scholar 

  15. R Jain S Gujar P McKeever P Robertson S Mukherji (2003) ArticleTitleImaging findings associated with childhood primary intracranial squamous cell carcinoma Case report. AJNR 24 109–111

    Google Scholar 

  16. Y Nosaka S Nagao K Tabuchi A Nishimoto (1979) ArticleTitlePrimary intracranial epidermoid carcinoma Case report. J Neurosurg 50 830–833

    Google Scholar 

  17. N Ogata W Jochum A Aguzzi JY Fournier Y Yonekawa (1996) ArticleTitleTotal removal of a primary intracranial squamous cell carcinoma invading the brain stem Surg Neurol 46 477–480 Occurrence Handle10.1016/S0090-3019(96)00222-4 Occurrence Handle8874550

    Article  PubMed  Google Scholar 

  18. Y Sahara T Nagasaka M Takayasu T Takagi N Hata J Yoshida (2001) ArticleTitleRecurrence of a neurenteric cyst with malignant transformation in the foramen magnum after total resection J Neurosurg 95 341–345 Occurrence Handle11780908

    PubMed  Google Scholar 

  19. LC Ho A Olivi CH Cho PC Burger F Simeone T Tihan (1998) ArticleTitleWell-differentiated papillary adenocarcinoma arising in supratentorial enterogenous cyst: case report Neurosurgery 43 1474–1477 Occurrence Handle10.1097/00006123-199812000-00131 Occurrence Handle9848864

    Article  PubMed  Google Scholar 

  20. I Vajtai D Tassi Z Varga J Tarjànyi E Vörös (1995) ArticleTitleCerebralis epidermoid cystàban kialakult malignus melanoma [Abstract] Orvosi Hetil 136 1171–1174

    Google Scholar 

  21. TC Cannon BL Bane D Kistler GW Schoenhals M Hahn RW Leech RA Brumback (1998) ArticleTitlePrimary intracerebellar osteosarcoma arising within an epidermoid cyst Arch Pathol Lab Med 122 737–739 Occurrence Handle9701337

    PubMed  Google Scholar 

  22. K Akachi H Takahashi B Ishijima NakamuraY M Oda T Takizawa M Iwamoto G Kuiyama K Shizuki (1987) ArticleTitleMalignant changes in a craniopharyngioma No Shinkei Geka 15 843–848 Occurrence Handle3431651

    PubMed  Google Scholar 

  23. T Kristopaitis C Thomas GJ Petruzzelli JM Lee (2000) ArticleTitleMalignant craniopharyngioma Arch Pathol Lab Med 124 1356–1360 Occurrence Handle10975938

    PubMed  Google Scholar 

  24. GA Nelson FO Bastian M Schlitt (1988) ArticleTitleMalignant transformation in craniopharyngioma: a case report J Neurosurg 22 427–429

    Google Scholar 

  25. H Samejima K Oka H Kimura K Kasai Y Ushikubo M Ueda K Takahashi M Hara (1997) ArticleTitleA study of malignant craniopharyngioma [Abstract] Clin Neurol Neurosurg 99 IssueID1 240 Occurrence Handle10.1016/S0303-8467(97)82396-7

    Article  Google Scholar 

  26. F Suzuki I Konuma M Matsumoto M Aoki I Hayakawa (1989) ArticleTitleCraniopharyngioma with malignant transformation – a report of two cases Gan No Rinsho 35 723–728 Occurrence Handle2657129

    PubMed  Google Scholar 

  27. T Kubokura T Nishimura K Tsubone (1986) ArticleTitleCT scan findings of malignant epidermoid cyst Case report Neurol Med Chir (Tokyo) 26 706–711

    Google Scholar 

  28. I Nishiura T Koyama J Handa S Amano (1989) ArticleTitlePrimary intracranial epidermoid carcinoma. Case report Neurol Med Chir (Tokyo) 29 600–605

    Google Scholar 

  29. Scully RE, Galdabini JJ, McNeely BU (eds): Case records of the Massachusetts General Hospital. N Engl J Med 296: 271–276, 1977

  30. J Salazar J Vaquero G Saucedo G Bravo (1987) ArticleTitlePosterior fossa epidermoid cysts Acta Neurochirurg (Wien) 85 34–39 Occurrence Handle10.1007/BF01402367

    Article  Google Scholar 

  31. AS Goldman SE Gandy (1987) ArticleTitleSquamous cell carcinoma as a late complication of intracerebroventricular epidermoid cyst. Case report J Neurosurg 66 618–620 Occurrence Handle3559730

    PubMed  Google Scholar 

  32. L Bondeson K Fält (1984) ArticleTitlePrimary intracranial epidermoid carcinoma Acta Cytol 28 487–489 Occurrence Handle6589931

    PubMed  Google Scholar 

  33. PJ Dubois M Sage S Luther PC Burger E Ralph-heinz BP Drayer (1981) ArticleTitleMalignant change in an intracranial epidermoid cyst J Comput Assist Tomogr 5 433–435 Occurrence Handle6972395

    PubMed  Google Scholar 

  34. P Michenet C Vital J Rivel B Lebail V Riemens (1989) ArticleTitleTransformation maligne d’un kyste epidermoide intra-cranien Ann Pathol 9 360–362 Occurrence Handle2610778

    PubMed  Google Scholar 

  35. R Monaco A Boscaino AD Blasi A D’Antonio G Profeta R De Falco O Nappi (2003) ArticleTitleIntraepithelial carcinoma arising in an endodermal cyst of the posterior fossa Neuropathology 23 219–224 Occurrence Handle10.1046/j.1440-1789.2003.00497.x Occurrence Handle14570291

    Article  PubMed  Google Scholar 

  36. M Takado G Hirose T Yamamoto H Kosoegawa F Konishi (1982) ArticleTitleAn autopsy case of primary parapontine epidermoid carcinoma Clin Neurol 22 579–585

    Google Scholar 

  37. JW Landers JJ Danielski (1960) ArticleTitleMalignant intracranial epidermoid cyst Arch Pathol 70 419–423 Occurrence Handle14461962

    PubMed  Google Scholar 

  38. RJ Knorr RL Ragland TW Smith RI Davidson JD Keller (1991) ArticleTitleSquamous carcinoma arising in a cerebellopontine angle epidermoid: CT and MR findings AJNR 12 1182–1184 Occurrence Handle1763747

    PubMed  Google Scholar 

  39. Radhakrishnan VV, Saraswathy A, Rout D: Squamous cell carcinoma arising in the remnant of an extirpated intracerebral epidermoid cyst. Ind J Pathol Microbiol Suppl: 27–28, 1994

  40. F Tognetti G Lanzino V Manetto F Calbucci (1991) ArticleTitleIntracranial squamous cell carcinoma arising in remnant of extirpated epidermoid cyst Br J Neurosurg 5 303–305 Occurrence Handle1892574

    PubMed  Google Scholar 

  41. S Komjatszegi GH Roth (1964) ArticleTitleTransformarea malignà a unui epidermoid leptomeningian bazal St Cerc Neurol 9 501–504

    Google Scholar 

  42. T Kobayashi H Kuchiwaki S Inao S Nakashima (1993) ArticleTitleA squamous cell carcinoma originated from intracranial dermoid cyst Neurochirurgia 36 26–29 Occurrence Handle8446293

    PubMed  Google Scholar 

  43. DR Maffazzoni LM Barbosa-Coutinho IM Chemalle E Maciel (1986) ArticleTitleCarcinoma originado em cisto epidermoide intracraniano Arquivos de neuropsiquiatria 44 391–394

    Google Scholar 

  44. S Nishio I Takeshita T Morioka M Fukui (1995) ArticleTitlePrimary intracranial squamous cell carcinomas: report of two cases Neurosurgery 37 329–332 Occurrence Handle7477788

    PubMed  Google Scholar 

  45. C Bayindir N Balak A Karasu (1996) ArticleTitleMicro-invasive squamous cell carcinoma arising in a pre-existing intraventricular epidermoid cyst. Case report and literature review Acta Neurochirurg (Wien) 138 1008–1012 Occurrence Handle10.1007/BF01411292

    Article  Google Scholar 

  46. F Giangaspero V Manetto R Ferratini G. Piazza (1990) ArticleTitleSquamous cell carcinoma of the brain with sarcoma-like stroma Virchows Arch (Pathol.Anat) 402 1041–1045

    Google Scholar 

  47. N Acciari R Padovani MP Foschini M Giulioni FS Finizo (1993) ArticleTitleIntracranial squamous cell carcinoma arising in an epidermoid cyst Br J Neurosurg 7 565–569 Occurrence Handle8267896

    PubMed  Google Scholar 

  48. K Ashkan P Wilkins H Marsh (2002) ArticleTitleSquamous cell carcinoma: a rare complication of dermoid cysts Neuropathol Appl Neurobiol 28 164–165 Occurrence Handle10.1046/j.1365-2990.2002.39286_44.x

    Article  Google Scholar 

  49. O Hatem G Bedou JL Bertrand J Camo C. Bousquet (2002) ArticleTitleCarcinome epidermoid primitif intracranien Neurochirurgie 48 109–112 Occurrence Handle12053167

    PubMed  Google Scholar 

  50. T Delangre C Hemet J Tayot Y Vaschalde P Augustin (1992) ArticleTitleMalignant degeneration of epidermoid cyst of the posterior cranial fossa. Diagnostic value of magnetic resonance imaging Rev Neurol 148 55–57 Occurrence Handle1604115

    PubMed  Google Scholar 

  51. A Mohanty VR Sastry kolluri V Santosh (1996) ArticleTitleSquamous cell carcinomatous change in a posterior fossa epidermoid: case report with a review of the literature Br J Neurosurg 10 493–495 Occurrence Handle10.1080/02688699647140 Occurrence Handle8922710

    Article  PubMed  Google Scholar 

  52. T Shirabe K Fukuoka A Watanabe K Imamura R Ishii (2003) ArticleTitlePrimary squamous cell carcinoma of the brain. A rare autopsy case Neuropathology 23 225–229 Occurrence Handle10.1046/j.1440-1789.2003.00499.x Occurrence Handle14570292

    Article  PubMed  Google Scholar 

  53. H Tsugu T Fukushima S Hayashi M Iwaasa T Matsuda (2001) ArticleTitleSquamous cell carcinoma arising in an intracranial dermoid cyst. A case report Neurol Med Chir (Tokyo) 41 213–216 Occurrence Handle10.2176/nmc.41.213

    Article  Google Scholar 

  54. H Gi H Yoshizumi S Nagao T Nishioka J Uno Y Fujita (1990) ArticleTitleAngle epidermoid carcinoma: a case report No Shinkei Geka 18 1041–1045 Occurrence Handle2247198

    PubMed  Google Scholar 

  55. T Asahi M Kurimoto S Endo F Monma M Ohi M Takami (2001) ArticleTitleMalignant transformation of cerebello-pontine angle epidermoid J Clin Neurosci 8 572–574 Occurrence Handle10.1054/jocn.2000.0856 Occurrence Handle11683611

    Article  PubMed  Google Scholar 

  56. O Hug (1942) ArticleTitleKrebsbildung aus einem pialen Epidermoid Virchows Arch (Pathol Anat) 308 679–689

    Google Scholar 

  57. D Kömpf HW Menges (1977) ArticleTitleMaligne Entartung eines parapontinen Epidermoids Akutes Conus-Cauda Syndrom infolge meningealer Aussaat. Acta Neurochirurg (Wien) 39 81–90

    Google Scholar 

  58. MJ Link PL Cohen JC Breneman JM Tew (2002) ArticleTitleMalignant squamous degeneration of cerebellopontine angle epidermoid tumor: case report J Neurosurg 97 1237–1243 Occurrence Handle12450053

    PubMed  Google Scholar 

  59. A Matsuno S Shibui C Ochiai H Inoya K Takakura (1987) ArticleTitlePrimary intracranial epidermoid carcinoam accompanied with epidermoid cyst in the cerebellopontine angle. A case report No Shinkei Geka 15 851–858 Occurrence Handle3323934

    PubMed  Google Scholar 

  60. Y Mori Y Suzuki T Tanasawa J Yoshida T Wakabayashi T Kobayashi (1995) ArticleTitleA case report of epidermoid carcinoma in the cerebello-pontine angle Neurol Surg 23 905–908

    Google Scholar 

  61. A Uchino K Hasuo S Matsumoto K Uda M Moriguchi T Nishio M Fukui K Masuda (1995) ArticleTitleIntracranial epidermoid carcinoma: CT and MRI Neuroradiology 37 155–158 Occurrence Handle7761005

    PubMed  Google Scholar 

  62. T Fuse T Takagi S Mizuno K Yamada (1995) ArticleTitlePrimary intracranial malignant epidermoid. Case report No To Shinkei 47 997–1001 Occurrence Handle7577146

    PubMed  Google Scholar 

  63. S Ishikawa M Yamazaki A Nakamura N. Hanyu (2000) ArticleTitleAn autopsy case of primary cerebellar-pontine angle epidermoid carcinoma Clin Neurol 40 243–248

    Google Scholar 

  64. RB Khan DD Giri MK Rosenblum FA Petito LM DeAngelis (2001) ArticleTitleLeptomeningeal metastasis from an intracranial epidermoid cyst Neurology 56 1419–1420 Occurrence Handle11376208

    PubMed  Google Scholar 

  65. S Murase H Yamakawa A Ohkuma Y Sumi M Kajiwara T Takami N Sakai (1999) ArticleTitlePrimary intracranial squamous cell carcinoma. Case report Neurol Med Chir (Tokyo) 39 49–54

    Google Scholar 

  66. A Yamanaka S Hinohara T Hashemoto (1955) ArticleTitlePrimary diffuses carcinomatosis of the spinal meninges accompanied with a cancerous epidermal cyst of the base of the brain. Report of a case of autopsy Gann 46 274–276

    Google Scholar 

  67. A Hamlat ZF Hua S Saikali J Egreteau Y Guegan (2003) ArticleTitleMalignant transformation of intracranial epidermoid cyst with leptomeningeal carcinomatosis: case report Acta Neurol Belg 103 221–224 Occurrence Handle15008508

    PubMed  Google Scholar 

  68. J Oertel J Piek JU Müller S Vogelgesang R Warzok RM Gaab (2002) ArticleTitlePosterior fossa squamous cell carcinoma due to dedifferentiation of a dermoid cyst in Klippel-Feil syndrome J Neurosurg 97 1244 Occurrence Handle12450054

    PubMed  Google Scholar 

  69. D Salyer D Carter (1973) ArticleTitleSquamous carcinoma arising in the pituitary gland Cancer 31 713–718 Occurrence Handle4693599

    PubMed  Google Scholar 

  70. JU Toglia MG Netsky E Alexander SuffixJr. (1965) ArticleTitleEpithelial (epidermoid) tumors of the cranium J Neurosurg 23 384–393 Occurrence Handle5853888

    PubMed  Google Scholar 

  71. M Vinchon B Pertuzon JP Lejeune R Assaker JP Pruvo JL Christiaens (1995) ArticleTitleIntradural epidermoid cysts of the cerebellopontine angle: diagnosis and surgery Neurosurgery 36 52–57 Occurrence Handle7708168

    PubMed  Google Scholar 

  72. H Nawashiro R Higo AM Tokumaru N Tsuzuki K Shima (2001) ArticleTitleDiffusion-weighted MRI of an intracranial epidermoid with malignant transformation Neuroradiology 43 891 Occurrence Handle10.1007/s002340100612 Occurrence Handle11688710

    Article  PubMed  Google Scholar 

  73. J Handa K Okamoto Y Nakasu S Nakasu Y Nakano (1981) ArticleTitleComputed tomography of intracranial epidermoid tumours with special reference to atypical features Acta Neurochirurg (Wien) 58 221–228 Occurrence Handle10.1007/BF01407128

    Article  Google Scholar 

  74. IF Braun TP Naidich NE Leeds M Koslow HM Zimmerman NE Chase (1977) ArticleTitleDense intracranial epidermoid tumors. Computed tomographic observations Radiology 122 717–719 Occurrence Handle841058

    PubMed  Google Scholar 

  75. RC Dunn SuffixJr CA Archer RL Rpport SuffixII LM Looi (1981) ArticleTitleUnusual CT-dense posterior fossa epidermoid cyst. Case report J Neurosurg 55 654–656 Occurrence Handle7277016

    PubMed  Google Scholar 

  76. H Poptani RK Gupta VK Jain R Roy R. Pandey (1995) ArticleTitleCystic intracranial mass lesions: possible role in vivo MR Spectroscopy in its differential diagnosis Magnetic Resonance Imaging 13 1019–1029 Occurrence Handle10.1016/0730-725X(95)00045-I Occurrence Handle8583866

    Article  PubMed  Google Scholar 

  77. J Klisch F Juengling J Spreer D Koch T Thiel M Büchert S Arnold F Feuerhake M Schumacher (2001) ArticleTitleLhermitte–Duclos disease: assessment with MR imaging, positron emission tomography, single-photon emission CT, and MR spectroscopy AJNR Am J Neuroradiol 22 824–830 Occurrence Handle11337322

    PubMed  Google Scholar 

  78. JL Klin RB Noto M Glantz (1996) ArticleTitleSingle-photon emission CT in the evaluation of recurrent brain tumor in patients treated with gamma knife radiosurgery or conventional radiation therapy AJNR Am J Neuroradiol 17 1681–1686 Occurrence Handle8896622

    PubMed  Google Scholar 

  79. M Castillo L Kwock SK. Mukherji (1996) ArticleTitleClinical applications of Proton MR Spectroscopy AJNR Am J Neuroradiol 17 1–15 Occurrence Handle8770242

    PubMed  Google Scholar 

  80. SK Mukherji M Gapany D Phillips B Neelon S O’Brien W McCartney S Buejenovich JS Parekh JP Noordzij M Castillo (1999) ArticleTitleThallium-201 single-photon emission CT versus CT for the detection of recurrent squamous cell carcinoma of the head and neck AJNR Am J Neuroradiol 20 1215–1220 Occurrence Handle10472974

    PubMed  Google Scholar 

  81. V Marks D. Marrack (1960) ArticleTitleTumour cells in the cerebrospinal fluid J Neurol Neurosurg Psychiatry 23 194–201 Occurrence Handle14421319

    PubMed  Google Scholar 

  82. JP Glass M Melamed NL Chernik JB. Posner (1979) ArticleTitleMalignant cells in cerebrospinal fluid (CSF): the meaning of a positive CSF cytology Neurology 29 1369–1375 Occurrence Handle573381

    PubMed  Google Scholar 

  83. JA Wagner JK Frost H Wisotzkey SuffixJr (1960) ArticleTitleSubarachnoid neoplasia: incidence and problems of diagnosis Southern Med J 53 1503–1508 Occurrence Handle13782504

    PubMed  Google Scholar 

  84. WH Theodore S. Gendelman (1981) ArticleTitleMeningeal carcinomatosis Arch Neurol 38 696–699 Occurrence Handle6975612

    PubMed  Google Scholar 

  85. MJ Nissenblatt (1981) ArticleTitleCarcinoma with unknown primary tumor (CUP syndrome) Southern Med J 74 1497–1502

    Google Scholar 

  86. FK Conley (1985) Epidermoid and dermoid tumors: clinical features and surgical management RH Wilkins SS Rengachary (Eds) Neurosurgery McGraw-Hill Book Company New York 668–673

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Service de Neurochirurgie, CHRU Pontchaillou, Rue Henry Le Guilloux, 35000, Rennes, Cedex 2, France

    Abderrahmane Hamlat, Zhi-Fen Hua & Yvon Guegan

  2. Departments of Pathology, CHUR Pontchaillou, Rennes, France

    Stephan Saikali

  3. Department of Medical Informatics, Centre Eugene Marquis, Rennes, France

    Jean François Laurent

  4. Departments of Medical Oncology, Centre Eugene Marquis, Rennes, France

    Daniel Gedouin

  5. Department of Radiotherapy, Centre Eugene Marquis, Rennes, France

    Mohamed Ben-Hassel

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  1. Abderrahmane Hamlat
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Hamlat, A., Hua, ZF., Saikali, S. et al. Malignant Transformation of Intra-Cranial Epithelial Cysts: Systematic Article Review. J Neurooncol 74, 187–194 (2005). https://doi.org/10.1007/s11060-004-5175-4

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