Abstract
Background: Gynaecologic neoplasms are reported to have the highest potential for developing of ischemic stroke.Objectives: The history of a female patient, in whom recurrent cerebral embolism was the first clinical sign of occult ovarian neoplasm is described and the casuistic literature to characterise this clinical phenomenon reviewed.Results: Among a large spectrum of neoplasms complicating with ischemic stroke, ovarian carcinoma is one of the most frequently reported in the casuistic literature. The source of systemic microembolisation is endocardits of non-infectious origin; the characteristic diagnostic findings are thrombocytopenia, elevated D-dimers level, and a specific stroke pattern in magnetic resonance imaging.Conclusion: Meticulous diagnosis in female, otherwise ‘healthy’ patients with ischemic stroke, to detect the underlying neoplastic disease is of paramount importance, as early surgical intervention on cancer promises successful therapy for both, cancer and thromboembolism.
Similar content being viewed by others
References
MJ Johnson MW Sproule J Paul (1999) ArticleTitleThe prevalence and associated variables of deep venous thrombosis in advanced cancer Clin Oncol (R Coll Radiol) 11 105–110
LR Rogers (2003) ArticleTitleCerebrovascular complications in cancer patients Neurol Clin 21 IssueID1 167–192
RL Bick (2003) ArticleTitleCancer-associated thrombosis N Engl J Med 349 IssueID2 109–111
MA Fanale SR Zeldenrust TJ Moynihan (2002) ArticleTitleSome unusual complications of malignancies: Case 2 Marantic endocarditis in advanced cancer. J Clin Oncol 20 IssueID19 4111–4114
G Chomette M Auriol D Baubion C de Frejacques (1980) ArticleTitleNon-bacterial thrombotic endocarditis Autopsy study, clinical and pathological correlations. Ann Med Intern 131 IssueID7 443–447
S Chaturvedi J Ansell L Recht (1994) ArticleTitleShould cerebral ischemic events in cancer patients be considered a manifestation of hypercoagulability Stroke 25 1215–1218
K Jahn T Pfefferkorn M Gropp G Hamann HW Pfister (1999) ArticleTitleZerebrale Ischämien als Erstmanifestation neoplastischer Veränderungen niedriger Malignität Nervenarzt 70 342–348
AD Blann GYH Lip (2001) ArticleTitleVirchow’s triad revisited: the importance of soluble coagulation factors, the endothelium and platelets Thromb Res 101 321–327
M Izumi S Terao J Takagi S Takatsu T Mitsuma (1996) ArticleTitleFavourable prognosis in a case of recurrent cerebral infarctions caused by chronic disseminated intravascular coagulation due to ovarian carcinoma No To Shinkei 48 IssueID6 581–585
J Cornuz J Bogusslavsky M Schapira F Regli E Camenzind (1988) ArticleTitleIschemic stroke as the presenting manifestation of localized systemic cancer Schweiz Arch Neurol Psychiatr 139 IssueID2 5–11
AB Singhal MA Topcuoglu FS Buonanno (2002) ArticleTitleAcute ischemic stroke patterns in infective and nonbacterial thrombotic endocarditis Stroke 33 1267–1273
A Shuaib (1991) ArticleTitleStroke from other etiologies masquerading as migraine-stroke Stroke 22 1068–1074
T Fennerty (2001) ArticleTitleScreening for cancer in venous thromboembolic disease BMJ 323 IssueID7315 704–705
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Borowski, A., Ghodsizad, A. & Gams, E. Stroke as a first manifestation of ovarian cancer. J Neurooncol 71, 267–269 (2005). https://doi.org/10.1007/s11060-004-1394-y
Issue Date:
DOI: https://doi.org/10.1007/s11060-004-1394-y