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Neuron and gliocyte death induced by photodynamic treatment: Signal processes and neuron-glial interactions

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Abstract

The mechanisms of photodynamic (PD) damage to neurons and gliocytes are discussed. The spike reactions of neurons are described, with stimulation at high concentrations of photosensitizer and inhibition at low concentrations, accompanying necrosis. Glial cells developed both necrosis and apoptosis. Local laser inactivation of neurons increased light-induced apoptosis of gliocytes, i.e., neurons maintained gliocyte survival. Inter-and intracellular signaling plays an important role in the photolesioning of these cells. Studies using inhibitors and activators of signal proteins demonstrated the involvement of the Ca2+-dependent, adenylate cyclase, and tyrosine kinase pathways in the responses of neurons and gliocytes to PD treatment. Pharmacological modulation may alter the selectivity of PD neuron and gliocyte damage and the efficacy of PD treatment.

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Authors and Affiliations

  1. A. B. Kogan institute of Neurocybernetics (Director: Professor B. M. Vladimirskii), Southern Federal University, Rostov-on-Don, Russia

    A. B. Uzdenskii, M. S. Kolosov & A. V. Lobanov

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  1. A. B. Uzdenskii
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  2. M. S. Kolosov
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  3. A. V. Lobanov
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Correspondence to A. B. Uzdenskii.

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Translated from Morfologiya, Vol. 132, No. 4, pp. 7–15, July–August, 2007.

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Uzdenskii, A.B., Kolosov, M.S. & Lobanov, A.V. Neuron and gliocyte death induced by photodynamic treatment: Signal processes and neuron-glial interactions. Neurosci Behav Physi 38, 727–735 (2008). https://doi.org/10.1007/s11055-008-9042-1

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  • DOI: https://doi.org/10.1007/s11055-008-9042-1

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