Abstract
Chronic psychoemotional stress induced by negative experience of social defeats in intermale confrontations over a period of 30 days was found to lead to the development of anxious-depressive symptomatology in male mice. Cessation of the psychopathogenic conditions and placing of depressed animals in comfortable conditions for 1–2 weeks with females did not lift the pathological state. Individuals continued to show marked anxiety, a behavioral deficit, decreased communicativeness, and a high level of depressivity, as revealed by a variety of behavioral tests. Persistence of the resulting psychoemotional disturbance in these animals is evidence for the development and persistence of the behavioral pathology requiring drug treatment.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 90, No. 10, pp. 1235–1245, October, 2004.
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Avgustinovich, D.F., Kovalenko, I.L. & Kudryavtseva, N.N. A Model of Anxious Depression: Persistence of Behavioral Pathology. Neurosci Behav Physiol 35, 917–924 (2005). https://doi.org/10.1007/s11055-005-0146-6
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DOI: https://doi.org/10.1007/s11055-005-0146-6