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Influence of the aggregation, concentration, and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia

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Abstract

Iron oxide nanoparticles have become ubiquitous in many biomedical applications, acting as core elements in an increasing number of therapeutic and diagnostic modalities. These applications mainly rely on their static and dynamic magnetic properties, through which they can be remotely actuated. However, little attention has been paid to understand the variation of the magnetic response of nanoparticles inside cells or tissues, despite of the remarkable changes reported to date. In this article, we provide some hints to analyze the influence of the biological matrix on the magnetism of iron oxide nanoparticles. To this aim, we propose the assessment of the heating efficiency of magnetic colloids against nanoparticle aggregation, concentration, and viscosity in order to mimic the fate of nanoparticles upon cell internalization.

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Acknowledgements

This work has been partially supported by European Commission (MULTIFUN, No. 262943), Spanish Ministry of Economy and Competitiveness (MAT2013-47395-C4-3-R), and Madrid Regional Government (NANOFRONTMAG-CM S2013/MIT-2850). F. J. T acknowledges financial support from Ramon y Cajal subprogram (RYC-2011-09617). We thank Dr. Gorka Salas for providing iron oxide nanoparticles, and Leonor de la Cueva and Rebeca Amaro for their technical assistance.

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Authors and Affiliations

  1. IMDEA Nanociencia, Ciudad Universitaria de Cantoblanco, 28049, Madrid, Spain

    David Cabrera, Julio Camarero, Daniel Ortega & Francisco J. Teran

  2. Dpto. Física Materia Condensada and Instituto “Nicolás Cabrera”, Universidad Autónoma de Madrid, 28049, Madrid, Spain

    Julio Camarero

  3. Institute of Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK

    Daniel Ortega

  4. Unidad Asociada de Nanobiotecnología, CNB-CSIC&IMDEA Nanociencia, Ciudad Universitaria de Cantoblanco, 28049, Madrid, Spain

    Daniel Ortega & Francisco J. Teran

Authors
  1. David Cabrera
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  2. Julio Camarero
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  3. Daniel Ortega
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  4. Francisco J. Teran
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Corresponding author

Correspondence to Francisco J. Teran.

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Guest Editor: Liudmyla Rieznichenko

This article is part of the topical collection on Engineered Bioinspired Nanomaterials

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Cabrera, D., Camarero, J., Ortega, D. et al. Influence of the aggregation, concentration, and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia. J Nanopart Res 17, 121 (2015). https://doi.org/10.1007/s11051-015-2921-9

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