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Structural organization of C60 fullerene, doxorubicin, and their complex in physiological solution as promising antitumor agents

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Abstract

Specific features of structural self-organization of C60 fullerene (1 nm size range), antitumor antibiotic doxorubicin (Dox) and their complex in physiological solution (0.9 % NaCl) have been investigated by means of atomic-force microscopy, dynamic light scattering, and small-angle X-ray scattering. Significant ordering of the mixed system, C60 + Dox, was observed, suggesting the complexation between these drugs, and giving insight into the mechanism of enhancement of Dox antitumor effect on simultaneous administration with C60 fullerene.

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Acknowledgments

This work was supported, in part, by Russian Science Fund, Project No. 14-14-00328.

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Authors and Affiliations

  1. Taras Shevchenko National University of Kyiv, Volodymyrska Str., 64, Kyiv, 01601, Ukraine

    Yu. I. Prylutskyy, O. A. Kyzyma, L. A. Bulavin & N. A. Davidenko

  2. Department of Biology and Chemistry, Belgorod State University, Pobedy Str. 85, 308015, Belgorod, Russia

    M. P. Evstigneev

  3. Institute of Physics of NAS of Ukraine, Nauky Aven., 46, Kyiv, 03680, Ukraine

    V. V. Cherepanov

  4. Joint Institute for Nuclear Research, Joliot-Curie Str. 6, 141980, Dubna, Moscow Region, Russia

    O. A. Kyzyma

  5. Ilmenau University of Technology, Weimarer Str. 25, 98693, Ilmenau, Germany

    P. Scharff

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  1. Yu. I. Prylutskyy
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  2. M. P. Evstigneev
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  3. V. V. Cherepanov
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  4. O. A. Kyzyma
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  5. L. A. Bulavin
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  6. N. A. Davidenko
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  7. P. Scharff
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Correspondence to M. P. Evstigneev.

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Prylutskyy, Y.I., Evstigneev, M.P., Cherepanov, V.V. et al. Structural organization of C60 fullerene, doxorubicin, and their complex in physiological solution as promising antitumor agents. J Nanopart Res 17, 45 (2015). https://doi.org/10.1007/s11051-015-2867-y

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  • DOI: https://doi.org/10.1007/s11051-015-2867-y

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