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Nanocrystalline magnesium oxide: an efficient promoter and heterogeneous nano catalyst for the one-pot synthesis of pyrazolotriazoles in green medium

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Abstract

A simple, efficient, and relatively clean method for the synthesis of pyrazolo[1,2-a][1,2,4]triazole derivatives via a one-pot three-component reaction of aromatic aldehydes, 4-phenyl-1,2,4-triazolidine-3,5-dione, and malononitrile or alkyl cyanoacetates in the presence of a catalytic amount of nanocrystalline (NC) magnesium oxide has been developed. This method has several advantages such as, high to excellent product yields, reusability of catalyst, and simple work-up procedure in the nontoxic medium.

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Acknowledgments

We are thankful from University of Kashan for supporting this study by Grant Number 159148/17, and also gratefully acknowledge financial support from the Avicenna Research Institute.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 87317, Kashan, Islamic Republic of Iran

    Hossein Naeimi & Zahra Rashid

  2. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, 1936773493, Tehran, Islamic Republic of Iran

    Amir-Hassan Zarnani

  3. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, 1936773493, Tehran, Islamic Republic of Iran

    Ramin Ghahremanzadeh

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  1. Hossein Naeimi
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  2. Zahra Rashid
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  3. Amir-Hassan Zarnani
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  4. Ramin Ghahremanzadeh
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Correspondence to Ramin Ghahremanzadeh.

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Naeimi, H., Rashid, Z., Zarnani, AH. et al. Nanocrystalline magnesium oxide: an efficient promoter and heterogeneous nano catalyst for the one-pot synthesis of pyrazolotriazoles in green medium. J Nanopart Res 16, 2416 (2014). https://doi.org/10.1007/s11051-014-2416-0

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