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Synthesis and evaluation of c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to tumor cell

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Abstract

We synthesized c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to α v β 3 integrin rich tumor cells (RDSP) by using a novel triplex hands coupling reagent tris-succinimidyl aminotriacetate and evaluated their structure, drug release, target cell uptake, and cytotoxic effects. Besides the high-trapping efficient for magnetic targeting, RDSP also has integrin α v β 3 targeting property. Moreover, RDSP shows a high-drug load ratio and can carry a large amount of doxorubicin to the target tumor cells. Compare with those of doxorubicin coupled DSP without peptide c(RGDyK) modification, RDSP shows an increase uptake by target tumor cells and stronger tumor cell cytotoxicity. This investigate provides an idiographic way for targeted delivery therapeutic agents to tumors with high efficiency and low-carrier toxicity.

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Acknowledgments

This study was financially supported by the Natural Science Foundation of China (NSFC21073091) and Natural Science Foundation of Jiangsu Province (No. BK2009009).

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Authors and Affiliations

  1. Key Laboratory of Mesoscopic Chemistry of MOE and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, People’s Republic of China

    Lin Guo & Wence Ding

  2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, People’s Republic of China

    Li-Min Zheng

Authors
  1. Lin Guo
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  2. Wence Ding
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  3. Li-Min Zheng
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Correspondence to Lin Guo.

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Guo, L., Ding, W. & Zheng, LM. Synthesis and evaluation of c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to tumor cell. J Nanopart Res 15, 1720 (2013). https://doi.org/10.1007/s11051-013-1720-4

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  • DOI: https://doi.org/10.1007/s11051-013-1720-4

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