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Toxicological effects of multi-wall carbon nanotubes in rats

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Abstract

The aim of this study was to evaluate the lung toxicity of multi-wall carbon nanotubes (MWCNTs). The present work exposed MWCNTs into the rats in intratracheal instillation administration modes. We systematically studied the distribution of nanoparticles in vivo, target organs and time-effects of nanotoxicity, dose-effects of nanotoxicity, etc. These results indicate that under the conditions of this test, pulmonary exposures to MWCNTs in rats by intratracheal instillation produced a series of multiple lesions in a dose-dependent and time-dependent manner, evidence of a foreign tissue body reaction.

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Acknowledgments

This work was supported by the National Nature Science Foundation of China (50672051, 30540061)

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Authors and Affiliations

  1. Key Laboratory of Liquid Structure and Heredity of Materials ministry of Education, Engineering Ceramics Key Laboratory of Shandong Province, Material Science and Engineering Institute, Shandong University, Jingshi road, Jinan, Shandong Province, 250061, P.R. China

    Aihong Liu, Kangning Sun & Jiafeng Yang

  2. The Second Hospital of Shandong University, Jinan, Shandong Province, 250070, P.R. China

    Jiafeng Yang & Dongmei Zhao

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  1. Aihong Liu
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  2. Kangning Sun
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  3. Jiafeng Yang
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  4. Dongmei Zhao
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Correspondence to Kangning Sun.

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Liu, A., Sun, K., Yang, J. et al. Toxicological effects of multi-wall carbon nanotubes in rats. J Nanopart Res 10, 1303–1307 (2008). https://doi.org/10.1007/s11051-008-9369-0

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  • DOI: https://doi.org/10.1007/s11051-008-9369-0

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