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Breakthrough Invasive Sinusitis by Hormographiella aspergillata in a Neutropenic Patient Receiving Voriconazole Therapy: A Case Report and Review of Breakthrough H. aspergillata Infections

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Abstract

Breakthrough invasive infections occurs during the use of antifungals both in prophylaxis and therapy, it favors the emergence of new pathogens in the fungal landscape. Hormographiella aspergillata is considered a rare but emerging pathogen in the era of broad-spectrum antifungal use in patients with hematological malignancies. Here, we present a case report of invasive sinusitis due to Hormographiella aspergillata, manifesting as a breakthrough infection in a patient with severe aplastic anemia under treatment with voriconazole for invasive pulmonary aspergilosis. Also, we make a review of H. aspergillata breakthrough infections published in the literature.

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Fig. 1
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Data Availability

All data generated, analyzed, and included in this study are available from the corresponding author.

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Acknowledgements

The authors would like to thank the microbiology team at the Hospital Pablo Tobón Uribe.

Funding

No financial support was provided relevant to this article.

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Authors and Affiliations

  1. Department of Internal Medicine, Infectious Diseases Division, School of Medicine, Universidad de Antioquia, Medellín, Colombia

    Ariel Fernando Florez-Riaño & Isabel Cristina Ramírez-Sánchez

  2. Department of Internal Medicine, Infectious Diseases Division. Hospital Pablo Tobón Uribe, Medellín, Colombia

    Isabel Cristina Ramírez-Sánchez

Authors
  1. Ariel Fernando Florez-Riaño
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  2. Isabel Cristina Ramírez-Sánchez
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Ariel Florez and Isabel Ramirez. The first draft of the manuscript was written by Ariel Florez and Isabel Ramirez, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Isabel Cristina Ramírez-Sánchez.

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Conflict of interest

Authors declare that they have no conflict of interest.

Ethics Approval and Consent to Participate

The protocol was approved by Hospital Pablo Tobón Uribe Ethics Committee.

Additional information

Handling Editor: Abdullah Mohammed Said Al-Hatmi .

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Florez-Riaño, A.F., Ramírez-Sánchez, I.C. Breakthrough Invasive Sinusitis by Hormographiella aspergillata in a Neutropenic Patient Receiving Voriconazole Therapy: A Case Report and Review of Breakthrough H. aspergillata Infections. Mycopathologia 188, 401–407 (2023). https://doi.org/10.1007/s11046-023-00768-4

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  • DOI: https://doi.org/10.1007/s11046-023-00768-4

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