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Deep Cutaneous Neoscytalidium dimidiatum Infection: Successful Outcome with Amphotericin B Therapy

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Abstract

Phaeohyphomycosis is a term used to describe a heterogenous group of cutaneous and systemic mycotic infections caused by melanized fungi. Many fungi have been reported as pathogens of this disease. The disease spectrum ranges from superficial cutaneous infections, deep cutaneous infections, to systemic infections with internal organ involvement. We report two cases of deep cutaneous phaeohyphomycosis on the foot clinically presenting as cellulitis with abscess formation. The pathogens were isolated from the lesion and both were identified as Neoscytalidium dimidiatum by their colony morphology, microscopic features, and sequences of internal transcribed spacers of ribosomal DNA. Both patients did not respond to the therapy with voriconazole and itraconazole, but improved after intravenous amphotericin B.

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Authors and Affiliations

  1. Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fushin Street, Taoyuan, Taiwan

    Shih-Jyun Yang, Chau-Yee Ng & Pei-Lun Sun

  2. Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan

    Ting-Shu Wu, Po-Yen Huang & Yen-Mu Wu

  3. College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Shih-Jyun Yang, Chau-Yee Ng, Ting-Shu Wu, Po-Yen Huang, Yen-Mu Wu & Pei-Lun Sun

  4. Research Laboratory of Medical Mycology, Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

    Pei-Lun Sun

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  1. Shih-Jyun Yang
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Correspondence to Pei-Lun Sun.

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Handling Editor: Vishnu Chaturvedi.

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Yang, SJ., Ng, CY., Wu, TS. et al. Deep Cutaneous Neoscytalidium dimidiatum Infection: Successful Outcome with Amphotericin B Therapy. Mycopathologia 184, 169–176 (2019). https://doi.org/10.1007/s11046-018-0308-z

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  • DOI: https://doi.org/10.1007/s11046-018-0308-z

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