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The First Reported Case of Canine Subcutaneous Cryptococcus flavescens Infection

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Abstract

This report describes the first documented case of subcutaneous infection due to Cryptococcus flavescens in a dog. The chief symptoms of the patient dog were abscessed lesions on the dorsal muzzle, right eyelid, and lower jaw. Biopsy specimens from the lesions on the dorsal muzzle and lower jaw showed pyogranulomatous inflammation with numerous yeast cells. The patient dog was diagnosed with a subcutaneous fungal infection and orally received 5 mg/kg itraconazole once a day for 2 months, the abscesses disappeared. After 1 month at the end of treatment, the skin lesions did not redevelop. Isolates from the biopsy specimens were identified as C. flavescens by molecular analysis as well as morphologic and biochemical examination, indicating that C. flavescens is a potential canine pathogen.

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Acknowledgments

This study was supported by grants-in-aid from the Academic Frontier Project of the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT), Nihon University and Kariya Animal Hospital.

Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

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Author notes

  1. Rui Kano

    Present address: Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan

Authors and Affiliations

  1. Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan

    Hiroshi Kamata

  2. Nakane Animal Hospital, 2-64-9 Akabane, Kita-ku, Tokyo, 115-0045, Japan

    Rinei Ishida & Shinsuke Nakane

  3. Department of Animal Science, Teikyo University of Science, 2-2-1 Senjyusakuragi, Adachi-ku, Tokyo, 120-0045, Japan

    Maiko Sekiguchi

  4. Institute of Medical Mycology, Teikyo University, 539 Otsuka, Hachioji, Tokyo, 192-0395, Japan

    Atsuhiko Hasegawa

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  1. Rui Kano
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  2. Rinei Ishida
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Correspondence to Rui Kano.

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Kano, R., Ishida, R., Nakane, S. et al. The First Reported Case of Canine Subcutaneous Cryptococcus flavescens Infection. Mycopathologia 173, 179–182 (2012). https://doi.org/10.1007/s11046-011-9479-6

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  • DOI: https://doi.org/10.1007/s11046-011-9479-6

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