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Increase in Candida parapsilosis Fungemia in Critical Care Units: A 6-Years Study

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Abstract

Objectives

We aimed to asses possible clinically significant differences between C. parapsilosis and other candida species candidemia receiving care in the intensive care unit (ICU) setting.

Methods

The study included 118 adult patients diagnosed as candidemia after admission to the ICU of a university hospital between January 2004 and December 2009. Data about demographic characteristics, underlying diseases, and risk factors for ICU-related candidemia were collected.

Results

During the study period, 118 patients with candidemia were identified among 2,853 patients admitted into the ICU. Candidemia was seen in 41.4 cases per 1,000 ICU admissions. The overall incidence of candidemia in ICU patients during the study period was 2.09 per 1,000 hospital admissions. Of the isolates, 18.6% were C. albicans and 81.4% were C. non-albicans. The species most frequently isolated was C. parapsilosis (66.1%, 78/118). The distribution of other Candida spp. was as follows: 15 had C. tropicalis (12.7%) and 3 had C. glabrata (2.5%). By Statistical analysis, when patients with candidemia who had C. parapsilosis were compared with other Candida spp., the following factors were found to be significantly associated with C. parapsilosis fungemia; intravascular catheters (p = 0.008), malignity (p = 0.049) and age (p = 0.039). Relationship was found between C. tropicalis and hematologic malignancies (p = 0.001).

Conclusions

When infections with a high mortality such as candidemia is suspected in critically ill patients, it is important to know local risk factors and epidemiological distributions of causative agents in selection of empirical and effective antifungal treatment.

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Authors and Affiliations

  1. Zeytinli Bahçe caddesi, Tıp Fakültesi Hastanesi, Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları, Mersin Üniversitesi, 33079, Mersin, Turkey

    Elif Şahin Horasan, Gülden Ersöz, Musa Göksu & Ali Kaya

  2. Faculty of Medicine, Department of Microbiology, Mersin University, Mersin, Turkey

    Feza Otag

  3. Faculty of Medicine, Department of Public Health, Mersin University, Mersin, Turkey

    Ahmet Oner Kurt

  4. Faculty of Medicine, Infection Control Committe, Mersin University, Mersin, Turkey

    Sevim Karaçorlu

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  1. Elif Şahin Horasan
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  2. Gülden Ersöz
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  3. Musa Göksu
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  4. Feza Otag
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  7. Ali Kaya
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Correspondence to Elif Şahin Horasan.

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Horasan, E.Ş., Ersöz, G., Göksu, M. et al. Increase in Candida parapsilosis Fungemia in Critical Care Units: A 6-Years Study. Mycopathologia 170, 263–268 (2010). https://doi.org/10.1007/s11046-010-9322-5

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  • DOI: https://doi.org/10.1007/s11046-010-9322-5

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