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Production of Antifungal Cellobiose Lipids by Trichosporon porosum

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Abstract

The yeast Trichosporon porosum suppresses growth of ascomycetes and basidiomycetes belonging to 52 genera. It is due to secretion of a thermostable fungicidal agent. The suppression was maximal at pH 3.5–4.0. Fungicidal preparation obtained from the culture broth was shown to be a mixture of cellobiosides of dihydrodecane acid with different degree of acetylation of cellobiose residue. The preparation caused the death of Candida albicans and Filobasidiella neoformans cells in the concentrations of 0.2 and 0.03 mM, respectively.

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Acknowledgments

The authors are grateful to the ChemBlock Ltd. Company for providing an access to a LCQ Finnigan MAT mass spectrometer and to Dr. V. V. Semenov for assistance. This study was supported by the Grant of support for the leading scientific schools of Russian Federation (NS-1004.2008.4.).

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Authors and Affiliations

  1. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, 142290, Pushchino, Moscow, Russia

    T. V. Kulakovskaya, W. I. Golubev, M. A. Tomashevskaya & E. V. Kulakovskaya

  2. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

    A. S. Shashkov, A. A. Grachev, A. S. Chizhov & N. E. Nifantiev

Authors
  1. T. V. Kulakovskaya
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  2. W. I. Golubev
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  3. M. A. Tomashevskaya
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  4. E. V. Kulakovskaya
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  5. A. S. Shashkov
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  6. A. A. Grachev
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  7. A. S. Chizhov
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  8. N. E. Nifantiev
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Correspondence to T. V. Kulakovskaya.

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Kulakovskaya, T.V., Golubev, W.I., Tomashevskaya, M.A. et al. Production of Antifungal Cellobiose Lipids by Trichosporon porosum . Mycopathologia 169, 117–123 (2010). https://doi.org/10.1007/s11046-009-9236-2

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  • DOI: https://doi.org/10.1007/s11046-009-9236-2

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